Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants
SARS-CoV-2 has recently been found to have spread from humans to minks and then to have transmitted back to humans. However, it is unknown to what extent the human-to-human transmission caused by the variant has reached. Here, we used publicly available SARS-CoV-2 genomic sequences from both humans...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-08-01
|
| Series: | The Innovation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666675821000539 |
| _version_ | 1818910389964898304 |
|---|---|
| author | Liang Wang Xavier Didelot Yuhai Bi George F. Gao |
| author_facet | Liang Wang Xavier Didelot Yuhai Bi George F. Gao |
| author_sort | Liang Wang |
| collection | DOAJ |
| description | SARS-CoV-2 has recently been found to have spread from humans to minks and then to have transmitted back to humans. However, it is unknown to what extent the human-to-human transmission caused by the variant has reached. Here, we used publicly available SARS-CoV-2 genomic sequences from both humans and minks collected in Denmark and the Netherlands, and combined phylogenetic analysis with Bayesian inference under an epidemiological model, to trace the possibility of person-to-person transmission. The results showed that at least 12.5% of all people being infected with dominated mink-derived SARS-CoV-2 variants in Denmark and the Netherlands were caused by human-to-human transmission, indicating that this “back-to-human” SARS-CoV-2 variant has already caused human-to-human transmission. Our study also indicated the need for monitoring this mink-derived and other animal source “back-to-human” SARS-CoV-2 in future and that prevention and control measures should be tailored to avoid large-scale community transmission caused by the virus jumping between animals and humans. Public summary: • SARS-CoV-2 transmission from human to mink is not lineage specific • Mink-derived SARS-CoV-2 variants keep human-to-human transmission • At least 12.5% of patients with mink-derived SARS-CoV-2 were caused by human-to-human transmission |
| first_indexed | 2024-12-19T22:42:02Z |
| format | Article |
| id | doaj.art-c30fbb265dd1401f8b4a8716d2fb6350 |
| institution | Directory Open Access Journal |
| issn | 2666-6758 |
| language | English |
| last_indexed | 2024-12-19T22:42:02Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Innovation |
| spelling | doaj.art-c30fbb265dd1401f8b4a8716d2fb63502022-12-21T20:03:03ZengElsevierThe Innovation2666-67582021-08-0123100128Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variantsLiang Wang0Xavier Didelot1Yuhai Bi2George F. Gao3CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing 100101, China; Corresponding authorSchool of Life Sciences and Department of Statistics, University of Warwick, Coventry CV4 7AL, UKCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China; Corresponding authorCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China; Corresponding authorSARS-CoV-2 has recently been found to have spread from humans to minks and then to have transmitted back to humans. However, it is unknown to what extent the human-to-human transmission caused by the variant has reached. Here, we used publicly available SARS-CoV-2 genomic sequences from both humans and minks collected in Denmark and the Netherlands, and combined phylogenetic analysis with Bayesian inference under an epidemiological model, to trace the possibility of person-to-person transmission. The results showed that at least 12.5% of all people being infected with dominated mink-derived SARS-CoV-2 variants in Denmark and the Netherlands were caused by human-to-human transmission, indicating that this “back-to-human” SARS-CoV-2 variant has already caused human-to-human transmission. Our study also indicated the need for monitoring this mink-derived and other animal source “back-to-human” SARS-CoV-2 in future and that prevention and control measures should be tailored to avoid large-scale community transmission caused by the virus jumping between animals and humans. Public summary: • SARS-CoV-2 transmission from human to mink is not lineage specific • Mink-derived SARS-CoV-2 variants keep human-to-human transmission • At least 12.5% of patients with mink-derived SARS-CoV-2 were caused by human-to-human transmissionhttp://www.sciencedirect.com/science/article/pii/S2666675821000539SARS-CoV-2minkhuman-to-human transmission |
| spellingShingle | Liang Wang Xavier Didelot Yuhai Bi George F. Gao Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants The Innovation SARS-CoV-2 mink human-to-human transmission |
| title | Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants |
| title_full | Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants |
| title_fullStr | Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants |
| title_full_unstemmed | Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants |
| title_short | Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants |
| title_sort | assessing the extent of community spread caused by mink derived sars cov 2 variants |
| topic | SARS-CoV-2 mink human-to-human transmission |
| url | http://www.sciencedirect.com/science/article/pii/S2666675821000539 |
| work_keys_str_mv | AT liangwang assessingtheextentofcommunityspreadcausedbyminkderivedsarscov2variants AT xavierdidelot assessingtheextentofcommunityspreadcausedbyminkderivedsarscov2variants AT yuhaibi assessingtheextentofcommunityspreadcausedbyminkderivedsarscov2variants AT georgefgao assessingtheextentofcommunityspreadcausedbyminkderivedsarscov2variants |