Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
Fibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeuti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16466-4 |
| _version_ | 1818683317902376960 |
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| author | Lu Cui Shih-Yu Chen Tristan Lerbs Jin-Wook Lee Pablo Domizi Sydney Gordon Yong-hun Kim Garry Nolan Paola Betancur Gerlinde Wernig |
| author_facet | Lu Cui Shih-Yu Chen Tristan Lerbs Jin-Wook Lee Pablo Domizi Sydney Gordon Yong-hun Kim Garry Nolan Paola Betancur Gerlinde Wernig |
| author_sort | Lu Cui |
| collection | DOAJ |
| description | Fibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeutic implications. |
| first_indexed | 2024-12-17T10:32:49Z |
| format | Article |
| id | doaj.art-c31003c7ba9446ada3f7ab8183096f6b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:32:49Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c31003c7ba9446ada3f7ab8183096f6b2022-12-21T21:52:29ZengNature PortfolioNature Communications2041-17232020-06-0111111410.1038/s41467-020-16466-4Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunityLu Cui0Shih-Yu Chen1Tristan Lerbs2Jin-Wook Lee3Pablo Domizi4Sydney Gordon5Yong-hun Kim6Garry Nolan7Paola Betancur8Gerlinde Wernig9Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of MedicineInstitute of Biomedical Sciences, Academia SinicaDepartment of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of MedicineDepartment of Genetics, Stanford University School of MedicineDepartment of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of MedicineOrca BiosystemsDepartment of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of MedicineBaxter Laboratories Department of Microbiology and Immunology, Stanford University School of MedicineDepartment of Radiation Oncology, University of CaliforniaDepartment of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of MedicineFibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeutic implications.https://doi.org/10.1038/s41467-020-16466-4 |
| spellingShingle | Lu Cui Shih-Yu Chen Tristan Lerbs Jin-Wook Lee Pablo Domizi Sydney Gordon Yong-hun Kim Garry Nolan Paola Betancur Gerlinde Wernig Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity Nature Communications |
| title | Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity |
| title_full | Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity |
| title_fullStr | Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity |
| title_full_unstemmed | Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity |
| title_short | Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity |
| title_sort | activation of jun in fibroblasts promotes pro fibrotic programme and modulates protective immunity |
| url | https://doi.org/10.1038/s41467-020-16466-4 |
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