Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub

Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub

Summary: Functional tags are ubiquitous in cell biology, and for studies of one chromosomal locus, the centromere, tags have been remarkably useful. The centromere directs chromosome inheritance at cell division. The location of the centromere is defined by a histone H3 variant, CENP-A. The regulati...

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Bibliographic Details
Main Authors: Catalina Salinas-Luypaert, Praveen Kumar Allu, Glennis A. Logsdon, Jennine M. Dawicki-McKenna, Craig W. Gambogi, Daniele Fachinetti, Ben E. Black
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
centromere
genome editing
CENP-A
histone variant
mitosis
functional protein tags
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013978

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