Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells
Nowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications. The present paper presents the development of a new immediate release tablet containing c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/1/45 |
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| author | Magdalena Mititelu Elena Moroșan Anca Cecilia Nicoară Ana Andreea Secăreanu Adina Magdalena Musuc Irina Atkinson Jeanina Pandele Cusu George Mihai Nițulescu Emma Adriana Ozon Iulian Sarbu Teodora Dalila Balaci |
| author_facet | Magdalena Mititelu Elena Moroșan Anca Cecilia Nicoară Ana Andreea Secăreanu Adina Magdalena Musuc Irina Atkinson Jeanina Pandele Cusu George Mihai Nițulescu Emma Adriana Ozon Iulian Sarbu Teodora Dalila Balaci |
| author_sort | Magdalena Mititelu |
| collection | DOAJ |
| description | Nowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications. The present paper presents the development of a new immediate release tablet containing calcium lactate obtained from Black Sea mussel shells. Compared with other calcium salts, calcium lactate has good solubility and bioavailability. In the pharmaceutical preparations, calcium lactate was extensively utilized as a calcium source for preventing and treating calcium deficiencies. The physical and chemical characteristics of synthesized calcium lactate were evaluated using Fourier Transform Infrared Spectroscopy, X-ray diffraction analysis and thermal analysis. Further, the various pharmacotechnical properties of the calcium lactate obtained from mussel shells were determined in comparison with an industrial used direct compressible Calcium lactate DC (PURACAL<sup>®</sup>). The obtained results suggest that mussel shell by-products are suitable for the development of chemical compounds with potential applications in the pharmaceutical domain. |
| first_indexed | 2024-03-10T01:05:47Z |
| format | Article |
| id | doaj.art-c3151246de9b46bdbc9a493559dd9121 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T01:05:47Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-c3151246de9b46bdbc9a493559dd91212023-11-23T14:27:55ZengMDPI AGMarine Drugs1660-33972022-01-012014510.3390/md20010045Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel ShellsMagdalena Mititelu0Elena Moroșan1Anca Cecilia Nicoară2Ana Andreea Secăreanu3Adina Magdalena Musuc4Irina Atkinson5Jeanina Pandele Cusu6George Mihai Nițulescu7Emma Adriana Ozon8Iulian Sarbu9Teodora Dalila Balaci10Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDepartment of Clinical Laboratory and Food Safety, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania“Ilie Murgulescu” Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania“Ilie Murgulescu” Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania“Ilie Murgulescu” Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, RomaniaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDepartment of Pharmaceutical Physics and Biophysics, Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, “Titu Maiorescu” University, 004051 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaNowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications. The present paper presents the development of a new immediate release tablet containing calcium lactate obtained from Black Sea mussel shells. Compared with other calcium salts, calcium lactate has good solubility and bioavailability. In the pharmaceutical preparations, calcium lactate was extensively utilized as a calcium source for preventing and treating calcium deficiencies. The physical and chemical characteristics of synthesized calcium lactate were evaluated using Fourier Transform Infrared Spectroscopy, X-ray diffraction analysis and thermal analysis. Further, the various pharmacotechnical properties of the calcium lactate obtained from mussel shells were determined in comparison with an industrial used direct compressible Calcium lactate DC (PURACAL<sup>®</sup>). The obtained results suggest that mussel shell by-products are suitable for the development of chemical compounds with potential applications in the pharmaceutical domain.https://www.mdpi.com/1660-3397/20/1/45calcium lactatemussel shellsphysical-chemical characterizationpreformulation studies |
| spellingShingle | Magdalena Mititelu Elena Moroșan Anca Cecilia Nicoară Ana Andreea Secăreanu Adina Magdalena Musuc Irina Atkinson Jeanina Pandele Cusu George Mihai Nițulescu Emma Adriana Ozon Iulian Sarbu Teodora Dalila Balaci Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells Marine Drugs calcium lactate mussel shells physical-chemical characterization preformulation studies |
| title | Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells |
| title_full | Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells |
| title_fullStr | Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells |
| title_full_unstemmed | Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells |
| title_short | Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells |
| title_sort | development of immediate release tablets containing calcium lactate synthetized from black sea mussel shells |
| topic | calcium lactate mussel shells physical-chemical characterization preformulation studies |
| url | https://www.mdpi.com/1660-3397/20/1/45 |
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