To explore the change of motor cognitive function in pituitary tumor rats after operation
AbstractTo study the changes of motor and cognitive function of pituitary tumor rats after the operation. Methods: The experiment was divided into three groups: control group, model group and operation group (30 animals for each group). Female Fischer344 rats were selected. Model group rats were sub...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Computer Assisted Surgery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/24699322.2023.2198099 |
| _version_ | 1797389837742899200 |
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| author | Hu Chang-Wei Ya-Bing Li Xiao-Yong Han Gang-Feng Yin Xi-Rui Wang |
| author_facet | Hu Chang-Wei Ya-Bing Li Xiao-Yong Han Gang-Feng Yin Xi-Rui Wang |
| author_sort | Hu Chang-Wei |
| collection | DOAJ |
| description | AbstractTo study the changes of motor and cognitive function of pituitary tumor rats after the operation. Methods: The experiment was divided into three groups: control group, model group and operation group (30 animals for each group). Female Fischer344 rats were selected. Model group rats were subcutaneously embedded with 10 mg estrogen sustained-release pump to induce a pituitary tumor model, and control group rats were subcutaneously embedded with a normal saline sustained-release pump as control. The operation group was successfully treated by microsurgery after the model was established. The quantitative expressions of PTTG, FGF-2 and VEGF were detected by Western blot. Morris test was used to detect the spatial learning and memory ability of rats. Western blot results showed that compared with the model group, the expression of the operation group was decreased, but still higher than that of the control group (p < 0.05). The water maze test results showed that the incubation period of searching the safe island in the model group was significantly longer than that in the control group on the 8th and 9th day after the injury, and the difference was statistically significant (p < 0.05). The incubation period of searching the safe island on the 8th and 9th day after injury in the operation group was significantly shorter than that in the control group. Through the detection of behavioral-related experimental and protein, the motor memory of rats after pituitary tumor surgery can be improved to some extent. |
| first_indexed | 2024-03-08T23:02:50Z |
| format | Article |
| id | doaj.art-c315793578ab4e99b87f47d51a1cdf40 |
| institution | Directory Open Access Journal |
| issn | 2469-9322 |
| language | English |
| last_indexed | 2024-03-08T23:02:50Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Computer Assisted Surgery |
| spelling | doaj.art-c315793578ab4e99b87f47d51a1cdf402023-12-15T16:06:58ZengTaylor & Francis GroupComputer Assisted Surgery2469-93222023-12-0128110.1080/24699322.2023.2198099To explore the change of motor cognitive function in pituitary tumor rats after operationHu Chang-Wei0Ya-Bing Li1Xiao-Yong Han2Gang-Feng Yin3Xi-Rui Wang4The Third Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, ChinaThe Third Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, ChinaThe Third Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, ChinaThe Third Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, ChinaThe Third Department of Neurosurgery, Cangzhou Central Hospital, Cangzhou, ChinaAbstractTo study the changes of motor and cognitive function of pituitary tumor rats after the operation. Methods: The experiment was divided into three groups: control group, model group and operation group (30 animals for each group). Female Fischer344 rats were selected. Model group rats were subcutaneously embedded with 10 mg estrogen sustained-release pump to induce a pituitary tumor model, and control group rats were subcutaneously embedded with a normal saline sustained-release pump as control. The operation group was successfully treated by microsurgery after the model was established. The quantitative expressions of PTTG, FGF-2 and VEGF were detected by Western blot. Morris test was used to detect the spatial learning and memory ability of rats. Western blot results showed that compared with the model group, the expression of the operation group was decreased, but still higher than that of the control group (p < 0.05). The water maze test results showed that the incubation period of searching the safe island in the model group was significantly longer than that in the control group on the 8th and 9th day after the injury, and the difference was statistically significant (p < 0.05). The incubation period of searching the safe island on the 8th and 9th day after injury in the operation group was significantly shorter than that in the control group. Through the detection of behavioral-related experimental and protein, the motor memory of rats after pituitary tumor surgery can be improved to some extent.https://www.tandfonline.com/doi/10.1080/24699322.2023.2198099Pituitary tumorPTTGFGF-2Morris water maze |
| spellingShingle | Hu Chang-Wei Ya-Bing Li Xiao-Yong Han Gang-Feng Yin Xi-Rui Wang To explore the change of motor cognitive function in pituitary tumor rats after operation Computer Assisted Surgery Pituitary tumor PTTG FGF-2 Morris water maze |
| title | To explore the change of motor cognitive function in pituitary tumor rats after operation |
| title_full | To explore the change of motor cognitive function in pituitary tumor rats after operation |
| title_fullStr | To explore the change of motor cognitive function in pituitary tumor rats after operation |
| title_full_unstemmed | To explore the change of motor cognitive function in pituitary tumor rats after operation |
| title_short | To explore the change of motor cognitive function in pituitary tumor rats after operation |
| title_sort | to explore the change of motor cognitive function in pituitary tumor rats after operation |
| topic | Pituitary tumor PTTG FGF-2 Morris water maze |
| url | https://www.tandfonline.com/doi/10.1080/24699322.2023.2198099 |
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