The application of HER2 and CD47 CAR-macrophage in ovarian cancer

The application of HER2 and CD47 CAR-macrophage in ovarian cancer

Abstract Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment. Macrophage is an important component...

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Bibliographic Details
Main Authors: Yizhao Chen, Xiangling Zhu, Hanze Liu, Cunzhi Wang, Yu Chen, Huihui Wang, Yilong Fang, Xuming Wu, Yuting Xu, Chunhua Li, Xinyue Lv, Jinghua Huang, Xintong Han, Ruilin Li, Wenming Hong, Zhiying Yu, Wei Wei, Jiajie Tu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
Chimeric antigen receptor
Macrophages
T cell
HER2
CD47
Immunotherapy
Online Access:https://doi.org/10.1186/s12967-023-04479-8

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