Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i>
Transcriptional regulation is vital for organismal survival, with many layers and mechanisms collaborating to balance gene expression. One layer of this regulation is genome organization, specifically the clustering of functionally related, co-expressed genes along the chromosomes. Spatial organizat...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/9/5/523 |
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| author | Gina M. Cittadino Johnathan Andrews Harpreet Purewal Pedro Estanislao Acuña Avila James T. Arnone |
| author_facet | Gina M. Cittadino Johnathan Andrews Harpreet Purewal Pedro Estanislao Acuña Avila James T. Arnone |
| author_sort | Gina M. Cittadino |
| collection | DOAJ |
| description | Transcriptional regulation is vital for organismal survival, with many layers and mechanisms collaborating to balance gene expression. One layer of this regulation is genome organization, specifically the clustering of functionally related, co-expressed genes along the chromosomes. Spatial organization allows for position effects to stabilize RNA expression and balance transcription, which can be advantageous for a number of reasons, including reductions in stochastic influences between the gene products. The organization of co-regulated gene families into functional clusters occurs extensively in <i>Ascomycota</i> fungi. However, this is less characterized within the related <i>Basidiomycota</i> fungi despite the many uses and applications for the species within this clade. This review will provide insight into the prevalence, purpose, and significance of the clustering of functionally related genes across <i>Dikarya</i>, including foundational studies from <i>Ascomycetes</i> and the current state of our understanding throughout representative <i>Basidiomycete</i> species. |
| first_indexed | 2024-03-11T03:35:51Z |
| format | Article |
| id | doaj.art-c317e6ed4f7742aea62d2680f205aedf |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-11T03:35:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
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| series | Journal of Fungi |
| spelling | doaj.art-c317e6ed4f7742aea62d2680f205aedf2023-11-18T02:01:43ZengMDPI AGJournal of Fungi2309-608X2023-04-019552310.3390/jof9050523Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i>Gina M. Cittadino0Johnathan Andrews1Harpreet Purewal2Pedro Estanislao Acuña Avila3James T. Arnone4Department of Biological and Environmental Sciences, Le Moyne College, Syracuse, NY 13214, USADepartment of Biological and Environmental Sciences, Le Moyne College, Syracuse, NY 13214, USADepartment of Biological and Environmental Sciences, Le Moyne College, Syracuse, NY 13214, USAUniversidad Tecnológica de Zinacantepec, San Bartolo el Llano, Zinacantepec 51361, MexicoDepartment of Biological and Environmental Sciences, Le Moyne College, Syracuse, NY 13214, USATranscriptional regulation is vital for organismal survival, with many layers and mechanisms collaborating to balance gene expression. One layer of this regulation is genome organization, specifically the clustering of functionally related, co-expressed genes along the chromosomes. Spatial organization allows for position effects to stabilize RNA expression and balance transcription, which can be advantageous for a number of reasons, including reductions in stochastic influences between the gene products. The organization of co-regulated gene families into functional clusters occurs extensively in <i>Ascomycota</i> fungi. However, this is less characterized within the related <i>Basidiomycota</i> fungi despite the many uses and applications for the species within this clade. This review will provide insight into the prevalence, purpose, and significance of the clustering of functionally related genes across <i>Dikarya</i>, including foundational studies from <i>Ascomycetes</i> and the current state of our understanding throughout representative <i>Basidiomycete</i> species.https://www.mdpi.com/2309-608X/9/5/523secondary metabolitesbiosynthetic gene clusterstranscriptional co-regulationgenome organizationposition effects<i>Dikarya</i> |
| spellingShingle | Gina M. Cittadino Johnathan Andrews Harpreet Purewal Pedro Estanislao Acuña Avila James T. Arnone Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i> Journal of Fungi secondary metabolites biosynthetic gene clusters transcriptional co-regulation genome organization position effects <i>Dikarya</i> |
| title | Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i> |
| title_full | Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i> |
| title_fullStr | Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i> |
| title_full_unstemmed | Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i> |
| title_short | Functional Clustering of Metabolically Related Genes Is Conserved across <i>Dikarya</i> |
| title_sort | functional clustering of metabolically related genes is conserved across i dikarya i |
| topic | secondary metabolites biosynthetic gene clusters transcriptional co-regulation genome organization position effects <i>Dikarya</i> |
| url | https://www.mdpi.com/2309-608X/9/5/523 |
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