Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum
Introduction. Agenesis of the corpus callosum is the most important change in white matter in the human brain. Absence of this structure can cause delayed motor development, mental retardation, seizures, language, or comprehension difficulties, with the progressive onset of autism, schizophrenia, a...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-12-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://rmj.com.ro/articles/2021.4/RMJ_2021_4_Art-18.pdf |
| _version_ | 1827330634911055872 |
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| author | Elisa Nica Mihai Mitran Bogdan Marinescu |
| author_facet | Elisa Nica Mihai Mitran Bogdan Marinescu |
| author_sort | Elisa Nica |
| collection | DOAJ |
| description | Introduction. Agenesis of the corpus callosum is the most important change in white matter in the human brain. Absence of this structure can cause delayed motor development, mental retardation, seizures, language, or comprehension
difficulties, with the progressive onset of autism, schizophrenia, and attention deficit disorders. Objectives. Advances in prenatal imaging techniques have led to a significant increase in the detection rate of agenesis of corpus callosum or associate anomalies – cranial and extracranial. Through this, we can advise parents earlier and check over time the development of affected children.
Materials and methods. We studied 23 cases of agenesis of corpus callosum, from which 15 of the women with this fetal diagnosis chose to give birth to 15 live newborns with this pathology, and we started to do follow up on the neurodevelopmental outcome of this children. Results. The outcome of neurological development for people with corpus callosum abnormalities is highly variable and there is often an overlap in neuropsychological performance between patients with complete agenesis and those with partial agenesis of corpus callosum. The 15 children evaluated showed a diverse evolution from normal to severe, with neuro-psychological regression found and proven over time. Conclusions. Given the unexpected shift from normal neurological, motor and cognitive functions to borderline and even severe ones, prenatal counseling regarding the prognosis of this disease is difficult. |
| first_indexed | 2024-03-07T16:15:15Z |
| format | Article |
| id | doaj.art-c3196fc464384e22bfa7a605cf78991b |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-03-07T16:15:15Z |
| publishDate | 2021-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-c3196fc464384e22bfa7a605cf78991b2024-03-04T12:03:41ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2021-12-0168450851210.37897/RMJ.2021.4.18Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosumElisa Nica0Mihai Mitran1Bogdan Marinescu2“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; CF 1 “Witting” Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Prof. Dr. Panait Sirbu” Clinical Hospital of Obstetrics and Gynecology, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Prof. Dr. Panait Sirbu” Clinical Hospital of Obstetrics and Gynecology, Bucharest, RomaniaIntroduction. Agenesis of the corpus callosum is the most important change in white matter in the human brain. Absence of this structure can cause delayed motor development, mental retardation, seizures, language, or comprehension difficulties, with the progressive onset of autism, schizophrenia, and attention deficit disorders. Objectives. Advances in prenatal imaging techniques have led to a significant increase in the detection rate of agenesis of corpus callosum or associate anomalies – cranial and extracranial. Through this, we can advise parents earlier and check over time the development of affected children. Materials and methods. We studied 23 cases of agenesis of corpus callosum, from which 15 of the women with this fetal diagnosis chose to give birth to 15 live newborns with this pathology, and we started to do follow up on the neurodevelopmental outcome of this children. Results. The outcome of neurological development for people with corpus callosum abnormalities is highly variable and there is often an overlap in neuropsychological performance between patients with complete agenesis and those with partial agenesis of corpus callosum. The 15 children evaluated showed a diverse evolution from normal to severe, with neuro-psychological regression found and proven over time. Conclusions. Given the unexpected shift from normal neurological, motor and cognitive functions to borderline and even severe ones, prenatal counseling regarding the prognosis of this disease is difficult.https://rmj.com.ro/articles/2021.4/RMJ_2021_4_Art-18.pdfagenesis of corpus callosumoutcomemalformationneurodevelopmental evolution |
| spellingShingle | Elisa Nica Mihai Mitran Bogdan Marinescu Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum Romanian Medical Journal agenesis of corpus callosum outcome malformation neurodevelopmental evolution |
| title | Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum |
| title_full | Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum |
| title_fullStr | Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum |
| title_full_unstemmed | Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum |
| title_short | Neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum |
| title_sort | neurodevelopmental outcome in children with a prenatal diagnosis of agenesis of corpus callosum |
| topic | agenesis of corpus callosum outcome malformation neurodevelopmental evolution |
| url | https://rmj.com.ro/articles/2021.4/RMJ_2021_4_Art-18.pdf |
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