Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy
Onychomycosis has been shown to have a higher incidence in cancer patients. Nail toxicity is a quite common side effect of anticancer agents. Taxotere© is a chemotherapeutic known to cause great incidence of nail change and has a role in subungual suppuration. We report on a 52-year-old woman with b...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-10-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://www.karger.com/Article/FullText/519695 |
| _version_ | 1818835911935262720 |
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| author | Yassine Merad Hichem Derrar Sarah Tabouri Faiza Berexi-Reguig |
| author_facet | Yassine Merad Hichem Derrar Sarah Tabouri Faiza Berexi-Reguig |
| author_sort | Yassine Merad |
| collection | DOAJ |
| description | Onychomycosis has been shown to have a higher incidence in cancer patients. Nail toxicity is a quite common side effect of anticancer agents. Taxotere© is a chemotherapeutic known to cause great incidence of nail change and has a role in subungual suppuration. We report on a 52-year-old woman with breast cancer admitted in our institution for onycholysis. Because of the stage and histology of breast cancer, neoadjuvant chemotherapy was initiated. The patient received 8 cycles of Taxotere and Adriamycin (AT), and she underwent a modified radical mastectomy. Three months later, the patient developed evidence of onycholysis, involving all the fingernails. We observed the following changes in nails of all the digits in both hands: onycholysis, dystrophy, oedema, and exudate. Nail scraping and purulent discharge were collected and cultured on Sabouraud medium. Physical features of the colonies and biochemical tests (Auxacolor©) revealed Candida guilliermondii as the sole etiologic agent of onychomycosis. This case details an onycholysis in a breast cancer case successfully managed solely with amorolfine lacquer. This clinical and mycological presentation should alert the clinician to the possibility of onychomycosis induced by docetaxel chemotherapy. |
| first_indexed | 2024-12-19T02:58:14Z |
| format | Article |
| id | doaj.art-c31abe6e08304127bd14563ccb36b1e7 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-19T02:58:14Z |
| publishDate | 2021-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-c31abe6e08304127bd14563ccb36b1e72022-12-21T20:38:17ZengKarger PublishersCase Reports in Oncology1662-65752021-10-011431530153510.1159/000519695519695Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel ChemotherapyYassine Merad0https://orcid.org/0000-0001-5671-684XHichem Derrar1Sarah Tabouri2Faiza Berexi-Reguig3Department of Parasitology-Mycology, Central Laboratory, Hassani “Abdelkader University Hospital,”, Sidi Bel Abbès, AlgeriaDepartment of Pulmonary and Lung Diseases, Sidi Bel Abbès, AlgeriaDepartement of Oncology, Centre Anti Cancer, Sidi Bel Abbès, AlgeriaDepartement of Oncology, Centre Anti Cancer, Sidi Bel Abbès, AlgeriaOnychomycosis has been shown to have a higher incidence in cancer patients. Nail toxicity is a quite common side effect of anticancer agents. Taxotere© is a chemotherapeutic known to cause great incidence of nail change and has a role in subungual suppuration. We report on a 52-year-old woman with breast cancer admitted in our institution for onycholysis. Because of the stage and histology of breast cancer, neoadjuvant chemotherapy was initiated. The patient received 8 cycles of Taxotere and Adriamycin (AT), and she underwent a modified radical mastectomy. Three months later, the patient developed evidence of onycholysis, involving all the fingernails. We observed the following changes in nails of all the digits in both hands: onycholysis, dystrophy, oedema, and exudate. Nail scraping and purulent discharge were collected and cultured on Sabouraud medium. Physical features of the colonies and biochemical tests (Auxacolor©) revealed Candida guilliermondii as the sole etiologic agent of onychomycosis. This case details an onycholysis in a breast cancer case successfully managed solely with amorolfine lacquer. This clinical and mycological presentation should alert the clinician to the possibility of onychomycosis induced by docetaxel chemotherapy.https://www.karger.com/Article/FullText/519695purulent dischargedocetaxelonychomycosiscandida guilliermondii |
| spellingShingle | Yassine Merad Hichem Derrar Sarah Tabouri Faiza Berexi-Reguig Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy Case Reports in Oncology purulent discharge docetaxel onychomycosis candida guilliermondii |
| title | Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy |
| title_full | Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy |
| title_fullStr | Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy |
| title_full_unstemmed | Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy |
| title_short | Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy |
| title_sort | candida guilliermondii onychomycosis involving fingernails in a breast cancer patient under docetaxel chemotherapy |
| topic | purulent discharge docetaxel onychomycosis candida guilliermondii |
| url | https://www.karger.com/Article/FullText/519695 |
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