An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer
Abstract Objective To determine the dose correlation between point B and metastatic lymph nodes in cervical cancer treated with three‐dimensional (3D) high‐dose‐rate (HDR) brachytherapy. Methods A retrospective study was conducted involving 30 cervical cancer patients with lymph node metastases who...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
|
| Series: | Precision Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pro6.1168 |
| _version_ | 1811238472358297600 |
|---|---|
| author | Dongming Yang Yuhua Gao |
| author_facet | Dongming Yang Yuhua Gao |
| author_sort | Dongming Yang |
| collection | DOAJ |
| description | Abstract Objective To determine the dose correlation between point B and metastatic lymph nodes in cervical cancer treated with three‐dimensional (3D) high‐dose‐rate (HDR) brachytherapy. Methods A retrospective study was conducted involving 30 cervical cancer patients with lymph node metastases who completed 3D HDR brachytherapy at Liaoning Cancer Hospital and Institute from May 2019 to November 2020. Brachytherapy was performed with a Fletcher applicator at a prescribed dose of 28 Gy/4 f. Computed tomography images of the external irradiation target were fused with delineated images of the brachytherapy target on the MIM system. The minimum dose received by 90% of the volume (D90) was read on the MIM system for all metastatic lymph nodes and the point B dose was read for the brachytherapy target area. In total, 78 metastatic lymph nodes from 30 patients with cervical cancer were included in this study, including para‐aortic, common iliac, external iliac, internal iliac, obturator, and inguinal lymph nodes. Paired t‐tests and Pearson correlation coefficient analyses were performed to examine the difference in the equivalent dose between each group of metastatic lymph nodes and point B. Results The mean equivalent point B dose was 6.69 ± 1.08 Gy. There were significant differences in dose between point B and the para‐aortic, common iliac, external iliac, internal iliac, and inguinal lymph nodes (p < 0.05), with a weak positive correlation (r < 0.4). There was no statistically significant difference in dose between obturator lymph nodes and point B (p = 0.3999), with a positive correlation (r = 0.65). Conclusion 3D HDR brachytherapy contributed significantly to pelvic lymph node doses in cervical cancer patients with lymph node metastasis, but less to para‐aortic and inguinal lymph node doses. The dose at point B grossly overestimated the mean dose to pelvic lymph nodes; only the dose to obturator lymph nodes was similar to that of point B, with a slightly positive correlation. |
| first_indexed | 2024-04-12T12:42:04Z |
| format | Article |
| id | doaj.art-c31c00345e6f46be9c2f2be1a501534d |
| institution | Directory Open Access Journal |
| issn | 2398-7324 |
| language | English |
| last_indexed | 2024-04-12T12:42:04Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Radiation Oncology |
| spelling | doaj.art-c31c00345e6f46be9c2f2be1a501534d2022-12-22T03:32:45ZengWileyPrecision Radiation Oncology2398-73242022-09-016320921510.1002/pro6.1168An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancerDongming Yang0Yuhua Gao1Department of Radiotherapy Liaoning Cancer Hospital & Institute Cancer Hospital of China Medical University Shenyang ChinaDepartment of Radiotherapy Liaoning Cancer Hospital & Institute Cancer Hospital of China Medical University Shenyang ChinaAbstract Objective To determine the dose correlation between point B and metastatic lymph nodes in cervical cancer treated with three‐dimensional (3D) high‐dose‐rate (HDR) brachytherapy. Methods A retrospective study was conducted involving 30 cervical cancer patients with lymph node metastases who completed 3D HDR brachytherapy at Liaoning Cancer Hospital and Institute from May 2019 to November 2020. Brachytherapy was performed with a Fletcher applicator at a prescribed dose of 28 Gy/4 f. Computed tomography images of the external irradiation target were fused with delineated images of the brachytherapy target on the MIM system. The minimum dose received by 90% of the volume (D90) was read on the MIM system for all metastatic lymph nodes and the point B dose was read for the brachytherapy target area. In total, 78 metastatic lymph nodes from 30 patients with cervical cancer were included in this study, including para‐aortic, common iliac, external iliac, internal iliac, obturator, and inguinal lymph nodes. Paired t‐tests and Pearson correlation coefficient analyses were performed to examine the difference in the equivalent dose between each group of metastatic lymph nodes and point B. Results The mean equivalent point B dose was 6.69 ± 1.08 Gy. There were significant differences in dose between point B and the para‐aortic, common iliac, external iliac, internal iliac, and inguinal lymph nodes (p < 0.05), with a weak positive correlation (r < 0.4). There was no statistically significant difference in dose between obturator lymph nodes and point B (p = 0.3999), with a positive correlation (r = 0.65). Conclusion 3D HDR brachytherapy contributed significantly to pelvic lymph node doses in cervical cancer patients with lymph node metastasis, but less to para‐aortic and inguinal lymph node doses. The dose at point B grossly overestimated the mean dose to pelvic lymph nodes; only the dose to obturator lymph nodes was similar to that of point B, with a slightly positive correlation.https://doi.org/10.1002/pro6.11683D brachytherapycervical cancerhigh‐dose‐ratemetastatic lymph nodespoint B |
| spellingShingle | Dongming Yang Yuhua Gao An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer Precision Radiation Oncology 3D brachytherapy cervical cancer high‐dose‐rate metastatic lymph nodes point B |
| title | An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer |
| title_full | An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer |
| title_fullStr | An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer |
| title_full_unstemmed | An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer |
| title_short | An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer |
| title_sort | exploratory study of the dose correlation between point b and metastatic lymph nodes in three dimensional high dose rate brachytherapy for cervical cancer |
| topic | 3D brachytherapy cervical cancer high‐dose‐rate metastatic lymph nodes point B |
| url | https://doi.org/10.1002/pro6.1168 |
| work_keys_str_mv | AT dongmingyang anexploratorystudyofthedosecorrelationbetweenpointbandmetastaticlymphnodesinthreedimensionalhighdoseratebrachytherapyforcervicalcancer AT yuhuagao anexploratorystudyofthedosecorrelationbetweenpointbandmetastaticlymphnodesinthreedimensionalhighdoseratebrachytherapyforcervicalcancer AT dongmingyang exploratorystudyofthedosecorrelationbetweenpointbandmetastaticlymphnodesinthreedimensionalhighdoseratebrachytherapyforcervicalcancer AT yuhuagao exploratorystudyofthedosecorrelationbetweenpointbandmetastaticlymphnodesinthreedimensionalhighdoseratebrachytherapyforcervicalcancer |