Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis

Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis

Renal fibrosis is characterized by progressive accumulation of extracellular matrix (ECM) proteins, resulting in loss of organ function and eventually requiring renal replacement therapy. Unfortunately, no efficacious treatment options are available to halt renal fibrosis and translational models to...

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Bibliographic Details
Main Authors: Elisabeth G. D. Stribos, Marc A. Seelen, Harry van Goor, Peter Olinga, Henricus A. M. Mutsaers
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
precision-cut kidney slices
ex vivo model
renal fibrosis
transforming-growth factor β
antifibrotic therapies
chronic kidney diseases
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01026/full

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