The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials
Background: Benign Prostatic Hyperplasia (BPH) is prevalent among elderly men, necessitating focused attention. The Prostatic Urethral Lift (PUL) procedure, a minimally invasive intervention, has emerged as a promising option for BPH management. It has shown remarkable results in ameliorating Lower...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2024-03-01
|
| Series: | Archivio Italiano di Urologia e Andrologia |
| Subjects: | |
| Online Access: | https://www.pagepressjournals.org/index.php/aiua/article/view/12066 |
| _version_ | 1797269204789886976 |
|---|---|
| author | Syah Mirsya Warli Muhammad Fahmi Ikram Raja Gerald Sarumpaet Zaimah Zulkarnaini Tala Ignatius Ivan Putrantyo |
| author_facet | Syah Mirsya Warli Muhammad Fahmi Ikram Raja Gerald Sarumpaet Zaimah Zulkarnaini Tala Ignatius Ivan Putrantyo |
| author_sort | Syah Mirsya Warli |
| collection | DOAJ |
| description |
Background: Benign Prostatic Hyperplasia (BPH) is prevalent among elderly men, necessitating focused attention. The Prostatic Urethral Lift (PUL) procedure, a minimally invasive intervention, has emerged as a promising option for BPH management. It has shown remarkable results in ameliorating Lower Urinary Tract Symptoms (LUTS), enhancing quality of life, and preserving sexual function. This study aims to evaluate the effectiveness and safety of PUL in BPH patients. Methods: Key databases (MEDLINE, Cochrane CENTRAL, ScienceDirect, EBSCO, Google Scholar) were systematically searched using pertinent terms related to PUL and BPH. Following the PRISMA checklist, we considered only Randomized Controlled Trials studies (RCTs) from 2013 to 2023. The assessment focused on LUTS, Quality of Life, sexual function, and Adverse Events, within three months. Follow-up post-treatment mean values compared with controls (Sham) and the improvement from baseline to post-treatment follow-up duration were considered. Statistical analysis and risk of bias evaluation were conducted using Review Manager 5.4.1, presenting results as difference of mean values (MD) and Risk Ratios (RR). Results: A meta-analysis with a Random Effects Model of 7 RCTs involving 378 confirmed BPH patients demonstrated significant improvements in the PUL arm including International Prostate Symptom Score (IPSS) (MD 5.51, p < 0.0001), maximum urinary flow rate (Qmax) (MD 2.13, p = 0.0001), BPH Impact Index (BPHII) (MD 2.14, p = 0.0001), and IPSS-QoL (MD 1.50, p < 0.0001), without significant increase of Adverse Events (RR 1.51; p = 0.50). Positive outcomes were observed in sexual function variables and post-void residual measurements when post-treatment values were compared to baseline. Conclusions: PUL holds advantages over control interventions, providing encouraging prospects for BPH management. This study underscores the need for further exploration of PUL's efficacy and safety in BPH patients.
|
| first_indexed | 2024-04-25T01:44:40Z |
| format | Article |
| id | doaj.art-c31c27b1f58d4c3aba48e471e4055653 |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-04-25T01:44:40Z |
| publishDate | 2024-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-c31c27b1f58d4c3aba48e471e40556532024-03-07T23:11:56ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972024-03-0110.4081/aiua.2024.12066The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trialsSyah Mirsya Warli0Muhammad Fahmi Ikram1Raja Gerald Sarumpaet2Zaimah Zulkarnaini Tala3Ignatius Ivan Putrantyo4Department of Urology, Universitas Sumatera Utara Hospital, Universitas Sumatera Utara, Medan; Division of Urology, Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara-Haji Adam Malik General Hospital, MedanFaculty of Medicine, Universitas Sumatera Utara, MedanFaculty of Medicine, Universitas Sumatera Utara, MedanDepartment of Nutrition, Faculty of Medicine, Universitas Sumatera UtaraDepartment of Urology, Faculty of Medicine, Universitas Indonesia - Haji Adam Malik General Hospital, Medan Background: Benign Prostatic Hyperplasia (BPH) is prevalent among elderly men, necessitating focused attention. The Prostatic Urethral Lift (PUL) procedure, a minimally invasive intervention, has emerged as a promising option for BPH management. It has shown remarkable results in ameliorating Lower Urinary Tract Symptoms (LUTS), enhancing quality of life, and preserving sexual function. This study aims to evaluate the effectiveness and safety of PUL in BPH patients. Methods: Key databases (MEDLINE, Cochrane CENTRAL, ScienceDirect, EBSCO, Google Scholar) were systematically searched using pertinent terms related to PUL and BPH. Following the PRISMA checklist, we considered only Randomized Controlled Trials studies (RCTs) from 2013 to 2023. The assessment focused on LUTS, Quality of Life, sexual function, and Adverse Events, within three months. Follow-up post-treatment mean values compared with controls (Sham) and the improvement from baseline to post-treatment follow-up duration were considered. Statistical analysis and risk of bias evaluation were conducted using Review Manager 5.4.1, presenting results as difference of mean values (MD) and Risk Ratios (RR). Results: A meta-analysis with a Random Effects Model of 7 RCTs involving 378 confirmed BPH patients demonstrated significant improvements in the PUL arm including International Prostate Symptom Score (IPSS) (MD 5.51, p < 0.0001), maximum urinary flow rate (Qmax) (MD 2.13, p = 0.0001), BPH Impact Index (BPHII) (MD 2.14, p = 0.0001), and IPSS-QoL (MD 1.50, p < 0.0001), without significant increase of Adverse Events (RR 1.51; p = 0.50). Positive outcomes were observed in sexual function variables and post-void residual measurements when post-treatment values were compared to baseline. Conclusions: PUL holds advantages over control interventions, providing encouraging prospects for BPH management. This study underscores the need for further exploration of PUL's efficacy and safety in BPH patients. https://www.pagepressjournals.org/index.php/aiua/article/view/12066Benign prostatic hyperplasialower urinary tract symptomsprostathic urethral liftquality of lifesexual function |
| spellingShingle | Syah Mirsya Warli Muhammad Fahmi Ikram Raja Gerald Sarumpaet Zaimah Zulkarnaini Tala Ignatius Ivan Putrantyo The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials Archivio Italiano di Urologia e Andrologia Benign prostatic hyperplasia lower urinary tract symptoms prostathic urethral lift quality of life sexual function |
| title | The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials |
| title_full | The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials |
| title_short | The efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | efficacy and safety of prostatic urethral lift as a minimally invasive therapeutic modality to treat lower urinary tract symptoms while maintaining sexual function in patients with benign prostatic hyperplasia a systematic review and meta analysis of randomized controlled trials |
| topic | Benign prostatic hyperplasia lower urinary tract symptoms prostathic urethral lift quality of life sexual function |
| url | https://www.pagepressjournals.org/index.php/aiua/article/view/12066 |
| work_keys_str_mv | AT syahmirsyawarli theefficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT muhammadfahmiikram theefficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT rajageraldsarumpaet theefficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT zaimahzulkarnainitala theefficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT ignatiusivanputrantyo theefficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT syahmirsyawarli efficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT muhammadfahmiikram efficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT rajageraldsarumpaet efficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT zaimahzulkarnainitala efficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT ignatiusivanputrantyo efficacyandsafetyofprostaticurethralliftasaminimallyinvasivetherapeuticmodalitytotreatlowerurinarytractsymptomswhilemaintainingsexualfunctioninpatientswithbenignprostatichyperplasiaasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |