Walking down Skeletal Muscle Lane: From Inflammasome to Disease
Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin do...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/3023 |
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| author | Nicolas Dubuisson Romain Versele María A. Davis-López de Carrizosa Camille M. Selvais Sonia M. Brichard Michel Abou-Samra |
| author_facet | Nicolas Dubuisson Romain Versele María A. Davis-López de Carrizosa Camille M. Selvais Sonia M. Brichard Michel Abou-Samra |
| author_sort | Nicolas Dubuisson |
| collection | DOAJ |
| description | Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) inflammasome is probably the best characterized. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. However, little is still known about NLRP3 implications in muscle disorders affecting non-cardiac muscles. In this review, we summarize and present the current knowledge regarding the function of NLRP3 in diseased skeletal muscle, and discuss the potential therapeutic options targeting the NLRP3 inflammasome in muscle disorders. |
| first_indexed | 2024-03-10T05:37:43Z |
| format | Article |
| id | doaj.art-c31c9aae9525475bbf1f29b986dc33c1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:43Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c31c9aae9525475bbf1f29b986dc33c12023-11-22T22:50:11ZengMDPI AGCells2073-44092021-11-011011302310.3390/cells10113023Walking down Skeletal Muscle Lane: From Inflammasome to DiseaseNicolas Dubuisson0Romain Versele1María A. Davis-López de Carrizosa2Camille M. Selvais3Sonia M. Brichard4Michel Abou-Samra5Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, BelgiumEndocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, BelgiumEndocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, BelgiumEndocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, BelgiumEndocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, BelgiumEndocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, BelgiumOver the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) inflammasome is probably the best characterized. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. However, little is still known about NLRP3 implications in muscle disorders affecting non-cardiac muscles. In this review, we summarize and present the current knowledge regarding the function of NLRP3 in diseased skeletal muscle, and discuss the potential therapeutic options targeting the NLRP3 inflammasome in muscle disorders.https://www.mdpi.com/2073-4409/10/11/3023skeletal muscleNLRP3inflammasomepyroptosismetabolic syndromesepsis |
| spellingShingle | Nicolas Dubuisson Romain Versele María A. Davis-López de Carrizosa Camille M. Selvais Sonia M. Brichard Michel Abou-Samra Walking down Skeletal Muscle Lane: From Inflammasome to Disease Cells skeletal muscle NLRP3 inflammasome pyroptosis metabolic syndrome sepsis |
| title | Walking down Skeletal Muscle Lane: From Inflammasome to Disease |
| title_full | Walking down Skeletal Muscle Lane: From Inflammasome to Disease |
| title_fullStr | Walking down Skeletal Muscle Lane: From Inflammasome to Disease |
| title_full_unstemmed | Walking down Skeletal Muscle Lane: From Inflammasome to Disease |
| title_short | Walking down Skeletal Muscle Lane: From Inflammasome to Disease |
| title_sort | walking down skeletal muscle lane from inflammasome to disease |
| topic | skeletal muscle NLRP3 inflammasome pyroptosis metabolic syndrome sepsis |
| url | https://www.mdpi.com/2073-4409/10/11/3023 |
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