Treadmill Exercise Prevents Decline in Spatial Learning and Memory in 3×Tg-AD Mice through Enhancement of Structural Synaptic Plasticity of the Hippocampus and Prefrontal Cortex

Treadmill Exercise Prevents Decline in Spatial Learning and Memory in 3×Tg-AD Mice through Enhancement of Structural Synaptic Plasticity of the Hippocampus and Prefrontal Cortex

Alzheimer’s disease (AD) is characterized by deficits in learning and memory. A pathological feature of AD is the alterations in the number and size of synapses, axon length, dendritic complexity, and dendritic spine numbers in the hippocampus and prefrontal cortex. Treadmill exercise can enhance sy...

Full description

Bibliographic Details
Main Authors: Lianwei Mu, Jiajia Cai, Boya Gu, Laikang Yu, Cui Li, Qing-Song Liu, Li Zhao
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
exercise
memory
synaptic
dendritic spines
structural synaptic plasticity
3×Tg-AD mice
Online Access:https://www.mdpi.com/2073-4409/11/2/244

Similar Items

Similar Items