Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature
Pipercillin-tazobactam is a frequently used antibiotic that has a broad spectrum of antibacterial activity. The development of severe thrombocytopenia following the use of piperacillin-tazobactam is unusual. Several mechanisms have been proposed for the pathogenesis of thrombocytopenia in this setti...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-08-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1468025 |
| _version_ | 1827816943183200256 |
|---|---|
| author | Musa Alzahrani Ibrahim Alrumaih Fahad Alhamad Ahmed Abdel Warith |
| author_facet | Musa Alzahrani Ibrahim Alrumaih Fahad Alhamad Ahmed Abdel Warith |
| author_sort | Musa Alzahrani |
| collection | DOAJ |
| description | Pipercillin-tazobactam is a frequently used antibiotic that has a broad spectrum of antibacterial activity. The development of severe thrombocytopenia following the use of piperacillin-tazobactam is unusual. Several mechanisms have been proposed for the pathogenesis of thrombocytopenia in this setting which include immune and non-immune causes. Multiple case reports have shown the ability of piperacillin-tazobactam to cause drug-induced immune thrombocytopenia, likely through formation of antibodies that recognize platelets in the presence of soluble piperacillin. However, severe and rapid development of thrombocytopenia that occurs in association with reexposure to piperacillin-tazobactam has not been clearly demonstrated in the literature. We present two cases in whom severe and rapid development of thrombocytopenia has occurred subsequent to administration of piperacillin-tazobactam with a prior history of recent exposure to the drug. In both cases, thrombocytopenia improved immediately and dramatically following withdrawal of piperacillin-tazobactam with initiation of steroids and intravenous immunoglubulins, suggesting and immune related drug-induced thrombocytopenia. |
| first_indexed | 2024-03-12T00:27:27Z |
| format | Article |
| id | doaj.art-c31e2fcc54e14e1399bab4de91e3ccac |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:27Z |
| publishDate | 2018-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-c31e2fcc54e14e1399bab4de91e3ccac2023-09-15T10:31:59ZengTaylor & Francis GroupPlatelets0953-71041369-16352018-08-0129662863110.1080/09537104.2018.14680251468025Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literatureMusa Alzahrani0Ibrahim Alrumaih1Fahad Alhamad2Ahmed Abdel Warith3King Khalid University Hospital, King Saud UniversityKing Saud UniversityKing Khalid University Hospital, King Saud UniversityKing Khalid University Hospital, King Saud UniversityPipercillin-tazobactam is a frequently used antibiotic that has a broad spectrum of antibacterial activity. The development of severe thrombocytopenia following the use of piperacillin-tazobactam is unusual. Several mechanisms have been proposed for the pathogenesis of thrombocytopenia in this setting which include immune and non-immune causes. Multiple case reports have shown the ability of piperacillin-tazobactam to cause drug-induced immune thrombocytopenia, likely through formation of antibodies that recognize platelets in the presence of soluble piperacillin. However, severe and rapid development of thrombocytopenia that occurs in association with reexposure to piperacillin-tazobactam has not been clearly demonstrated in the literature. We present two cases in whom severe and rapid development of thrombocytopenia has occurred subsequent to administration of piperacillin-tazobactam with a prior history of recent exposure to the drug. In both cases, thrombocytopenia improved immediately and dramatically following withdrawal of piperacillin-tazobactam with initiation of steroids and intravenous immunoglubulins, suggesting and immune related drug-induced thrombocytopenia.http://dx.doi.org/10.1080/09537104.2018.1468025antibioticsdrug-induced thrombocytopeniapiperacillin-tazobactam |
| spellingShingle | Musa Alzahrani Ibrahim Alrumaih Fahad Alhamad Ahmed Abdel Warith Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature Platelets antibiotics drug-induced thrombocytopenia piperacillin-tazobactam |
| title | Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature |
| title_full | Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature |
| title_fullStr | Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature |
| title_full_unstemmed | Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature |
| title_short | Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature |
| title_sort | rapid onset severe thrombocytopenia following reexposure to piperacillin tazobactam report of two cases and review of the literature |
| topic | antibiotics drug-induced thrombocytopenia piperacillin-tazobactam |
| url | http://dx.doi.org/10.1080/09537104.2018.1468025 |
| work_keys_str_mv | AT musaalzahrani rapidonsetseverethrombocytopeniafollowingreexposuretopiperacillintazobactamreportoftwocasesandreviewoftheliterature AT ibrahimalrumaih rapidonsetseverethrombocytopeniafollowingreexposuretopiperacillintazobactamreportoftwocasesandreviewoftheliterature AT fahadalhamad rapidonsetseverethrombocytopeniafollowingreexposuretopiperacillintazobactamreportoftwocasesandreviewoftheliterature AT ahmedabdelwarith rapidonsetseverethrombocytopeniafollowingreexposuretopiperacillintazobactamreportoftwocasesandreviewoftheliterature |