Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit
Tobacco (Nicotiana tabacum) is a plant that can be used as a natural insecticide. Tobacco extracts can be made as alternative nanoinsecticides to be used as Aedes aegypti control. This study aims to obtain information on the toxicity of tobacco nanoinsecticides and obtain the LD50 of tobacco nanoins...
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| Format: | Article |
| Language: | Indonesian |
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Politeknik Kesehatan Tanjung Karang
2022-12-01
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| Series: | Jurnal Kesehatan |
| Subjects: | |
| Online Access: | https://ejurnal.poltekkes-tjk.ac.id/index.php/JK/article/view/3229 |
| _version_ | 1797352581494734848 |
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| author | Sri Wahyuni Handayani Dwi Susilo Arum Triyas Wardani Yusnita Mirna Anggraeni |
| author_facet | Sri Wahyuni Handayani Dwi Susilo Arum Triyas Wardani Yusnita Mirna Anggraeni |
| author_sort | Sri Wahyuni Handayani |
| collection | DOAJ |
| description | Tobacco (Nicotiana tabacum) is a plant that can be used as a natural insecticide. Tobacco extracts can be made as alternative nanoinsecticides to be used as Aedes aegypti control. This study aims to obtain information on the toxicity of tobacco nanoinsecticides and obtain the LD50 of tobacco nanoinsecticides in mice. The research was conducted at the Center for Disease Vector and Reservoir Research and Development (B2P2VRP) with a pure experimental method. The results showed that the particle size ranged from 26.9; 53.7 and 89nm. The results of the metal content test with an Atomic Absorption Spectrophotometer (AAS) showed the presence of Ag content in the nanoinsecticide solution made. Spectrophotometry measurements showed a peak at a wavelength of 420 nm and functional group bonds were formed. The characteristic SEM photo shows the particle morphology in the form of round-face crystals. The results of the toxicity test using the OECD 423 LD50 method at 2500mg/kg BB showed that tobacco nanoinsecticides were in the slightly toxic category. Administration of tobacco nanoinsecticides causes toxic symptoms in the form of decreased cardiac activity, convulsions, and decreased movement activity, while from the histopathological test results, the number of kidney injuries is in the range of 10 to 25%. |
| first_indexed | 2024-03-08T13:19:01Z |
| format | Article |
| id | doaj.art-c32139db50fc4e51a05f503369ae5934 |
| institution | Directory Open Access Journal |
| issn | 2086-7751 2548-5695 |
| language | Indonesian |
| last_indexed | 2024-03-08T13:19:01Z |
| publishDate | 2022-12-01 |
| publisher | Politeknik Kesehatan Tanjung Karang |
| record_format | Article |
| series | Jurnal Kesehatan |
| spelling | doaj.art-c32139db50fc4e51a05f503369ae59342024-01-18T04:20:46ZindPoliteknik Kesehatan Tanjung KarangJurnal Kesehatan2086-77512548-56952022-12-0113355456110.26630/jk.v13i3.32291436Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap MencitSri Wahyuni Handayani0Dwi Susilo1Arum Triyas Wardani2Yusnita Mirna Anggraeni3Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit SalatigaBalai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit SalatigaBalai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit SalatigaBadan Riset dan Inovasi Nasional, IndonesiaTobacco (Nicotiana tabacum) is a plant that can be used as a natural insecticide. Tobacco extracts can be made as alternative nanoinsecticides to be used as Aedes aegypti control. This study aims to obtain information on the toxicity of tobacco nanoinsecticides and obtain the LD50 of tobacco nanoinsecticides in mice. The research was conducted at the Center for Disease Vector and Reservoir Research and Development (B2P2VRP) with a pure experimental method. The results showed that the particle size ranged from 26.9; 53.7 and 89nm. The results of the metal content test with an Atomic Absorption Spectrophotometer (AAS) showed the presence of Ag content in the nanoinsecticide solution made. Spectrophotometry measurements showed a peak at a wavelength of 420 nm and functional group bonds were formed. The characteristic SEM photo shows the particle morphology in the form of round-face crystals. The results of the toxicity test using the OECD 423 LD50 method at 2500mg/kg BB showed that tobacco nanoinsecticides were in the slightly toxic category. Administration of tobacco nanoinsecticides causes toxic symptoms in the form of decreased cardiac activity, convulsions, and decreased movement activity, while from the histopathological test results, the number of kidney injuries is in the range of 10 to 25%.https://ejurnal.poltekkes-tjk.ac.id/index.php/JK/article/view/3229micetobacco nanoinsecticidetoxicity test. |
| spellingShingle | Sri Wahyuni Handayani Dwi Susilo Arum Triyas Wardani Yusnita Mirna Anggraeni Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit Jurnal Kesehatan mice tobacco nanoinsecticide toxicity test. |
| title | Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit |
| title_full | Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit |
| title_fullStr | Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit |
| title_full_unstemmed | Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit |
| title_short | Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit |
| title_sort | uji toksisitas akut nanoinsektisida tembakau nicotiana tabacum l terhadap mencit |
| topic | mice tobacco nanoinsecticide toxicity test. |
| url | https://ejurnal.poltekkes-tjk.ac.id/index.php/JK/article/view/3229 |
| work_keys_str_mv | AT sriwahyunihandayani ujitoksisitasakutnanoinsektisidatembakaunicotianatabacumlterhadapmencit AT dwisusilo ujitoksisitasakutnanoinsektisidatembakaunicotianatabacumlterhadapmencit AT arumtriyaswardani ujitoksisitasakutnanoinsektisidatembakaunicotianatabacumlterhadapmencit AT yusnitamirnaanggraeni ujitoksisitasakutnanoinsektisidatembakaunicotianatabacumlterhadapmencit |