Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis
Aging is a growing problem worldwide, and the prevalence and mortality of arterial and venous thromboembolism (VTE) are higher in the elderly than in the young population. To address this issue, various anticoagulants have been used. However, no evidence can confirm that antithrombotic agents are su...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/11/2944 |
| _version_ | 1797460071071875072 |
|---|---|
| author | Seung Hee Lee Suyeon Cho Jong Youl Lee Jung Yeon Hong Suji Kim Myong-Ho Jeong Won-Ho Kim |
| author_facet | Seung Hee Lee Suyeon Cho Jong Youl Lee Jung Yeon Hong Suji Kim Myong-Ho Jeong Won-Ho Kim |
| author_sort | Seung Hee Lee |
| collection | DOAJ |
| description | Aging is a growing problem worldwide, and the prevalence and mortality of arterial and venous thromboembolism (VTE) are higher in the elderly than in the young population. To address this issue, various anticoagulants have been used. However, no evidence can confirm that antithrombotic agents are suitable for the elderly. Therefore, this study aims to investigate the platelet proteome of aged mice and identify antithrombotic drug targets specific to the elderly. Based on the proteome analysis of platelets from aged mice, 308 increased or decreased proteins were identified. Among these proteins, three targets were selected as potential antithrombotic drug targets. These targets are membrane proteins or related to platelet function and include beta-2-glycoprotein 1 (β2GP1, ApolipoproteinH (ApoH)), alpha-1-acid glycoprotein2 (AGP2, Orosomucoid-2 (Orm2)), and Ras-related protein (Rab11a). |
| first_indexed | 2024-03-09T17:00:55Z |
| format | Article |
| id | doaj.art-c3219483d1d847eba1ba1ff4342ea889 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:00:55Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c3219483d1d847eba1ba1ff4342ea8892023-11-24T14:30:51ZengMDPI AGBiomedicines2227-90592023-10-011111294410.3390/biomedicines11112944Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic AnalysisSeung Hee Lee0Suyeon Cho1Jong Youl Lee2Jung Yeon Hong3Suji Kim4Myong-Ho Jeong5Won-Ho Kim6Division of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaDivision of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaDivision of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaDivision of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaDivision of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaDivision of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaDivision of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si 28159, Republic of KoreaAging is a growing problem worldwide, and the prevalence and mortality of arterial and venous thromboembolism (VTE) are higher in the elderly than in the young population. To address this issue, various anticoagulants have been used. However, no evidence can confirm that antithrombotic agents are suitable for the elderly. Therefore, this study aims to investigate the platelet proteome of aged mice and identify antithrombotic drug targets specific to the elderly. Based on the proteome analysis of platelets from aged mice, 308 increased or decreased proteins were identified. Among these proteins, three targets were selected as potential antithrombotic drug targets. These targets are membrane proteins or related to platelet function and include beta-2-glycoprotein 1 (β2GP1, ApolipoproteinH (ApoH)), alpha-1-acid glycoprotein2 (AGP2, Orosomucoid-2 (Orm2)), and Ras-related protein (Rab11a).https://www.mdpi.com/2227-9059/11/11/2944plateletsagingantiplatelet therapyproteomics |
| spellingShingle | Seung Hee Lee Suyeon Cho Jong Youl Lee Jung Yeon Hong Suji Kim Myong-Ho Jeong Won-Ho Kim Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis Biomedicines platelets aging antiplatelet therapy proteomics |
| title | Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis |
| title_full | Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis |
| title_fullStr | Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis |
| title_full_unstemmed | Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis |
| title_short | Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis |
| title_sort | identification of potential drug targets for antiplatelet therapy specifically targeting platelets of old individuals through proteomic analysis |
| topic | platelets aging antiplatelet therapy proteomics |
| url | https://www.mdpi.com/2227-9059/11/11/2944 |
| work_keys_str_mv | AT seungheelee identificationofpotentialdrugtargetsforantiplatelettherapyspecificallytargetingplateletsofoldindividualsthroughproteomicanalysis AT suyeoncho identificationofpotentialdrugtargetsforantiplatelettherapyspecificallytargetingplateletsofoldindividualsthroughproteomicanalysis AT jongyoullee identificationofpotentialdrugtargetsforantiplatelettherapyspecificallytargetingplateletsofoldindividualsthroughproteomicanalysis AT jungyeonhong identificationofpotentialdrugtargetsforantiplatelettherapyspecificallytargetingplateletsofoldindividualsthroughproteomicanalysis AT sujikim identificationofpotentialdrugtargetsforantiplatelettherapyspecificallytargetingplateletsofoldindividualsthroughproteomicanalysis AT myonghojeong identificationofpotentialdrugtargetsforantiplatelettherapyspecificallytargetingplateletsofoldindividualsthroughproteomicanalysis AT wonhokim identificationofpotentialdrugtargetsforantiplatelettherapyspecificallytargetingplateletsofoldindividualsthroughproteomicanalysis |