Increased Renal Medullary NOX-4 in Female but Not Male Mice during the Early Phase of Type 1 Diabetes: Potential Role of ROS in Upregulation of TGF-β1 and Fibronectin in Collecting Duct Cells

Increased Renal Medullary NOX-4 in Female but Not Male Mice during the Early Phase of Type 1 Diabetes: Potential Role of ROS in Upregulation of TGF-β1 and Fibronectin in Collecting Duct Cells

Chronic diabetes mellitus (DM) can lead to kidney damage associated with increased reactive oxygen species (ROS), proteinuria, and tubular damage. Altered protein expression levels of transforming growth factor-beta 1 (TGF-β1), fibronectin, and renal NADPH oxidase (NOX-4) are associated with the pro...

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Bibliographic Details
Main Authors: Felipe Casado-Barragán, Geraldine Lazcano-Páez, Paulina E. Larenas, Monserrat Aguirre-Delgadillo, Fernanda Olivares-Aravena, Daniela Witto-Oyarce, Camila Núñez-Allimant, Katherin Silva, Quynh My Nguyen, Pilar Cárdenas, Modar Kassan, Alexis A. Gonzalez
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Antioxidants
Subjects:
diabetes
ROS
sex differences
mice
fibrotic factors
Online Access:https://www.mdpi.com/2076-3921/12/3/729

Internet

https://www.mdpi.com/2076-3921/12/3/729

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