A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma
Thalidomide is an effective chemotherapeutic agent used to achieve remission in multiple myeloma. However, its administration is associated with several adverse effects including venous thromboembolism, while arterial thrombosis has also, although rarely, been described in the literature. We report...
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2016-06-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | http://ejcrim.com/index.php/EJCRIM/article/view/410 |
| _version_ | 1828356392027684864 |
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| author | Maria Angela Grima David James Camilleri |
| author_facet | Maria Angela Grima David James Camilleri |
| author_sort | Maria Angela Grima |
| collection | DOAJ |
| description | Thalidomide is an effective chemotherapeutic agent used to achieve remission in multiple myeloma. However, its administration is associated with several adverse effects including venous thromboembolism, while arterial thrombosis has also, although rarely, been described in the literature. We report a case of internal carotid artery occlusion within 1 week of starting thalidomide with prophylactic low molecular weight heparin in a patient who had no other prothrombotic risk factors. It is not known why this complication occurs despite the administration of anticoagulant prophylaxis. The role of factor VIII, von Willebrand factor antigen levels and fibrinogen in multiple myeloma patients should be studied in order to determine if these factors should be targeted in future prophylactic treatment. |
| first_indexed | 2024-04-14T02:58:30Z |
| format | Article |
| id | doaj.art-c3260b900c1f4d40a5490e01ba079fe1 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-04-14T02:58:30Z |
| publishDate | 2016-06-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-c3260b900c1f4d40a5490e01ba079fe12022-12-22T02:16:01ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942016-06-013410.12890/2016_000410152A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple MyelomaMaria Angela Grima0David James Camilleri1Department of Health, Mater Dei Hospital, Triq Dun Karm, L-ImsidaDepartment of Health, Mater Dei Hospital, Triq Dun Karm, L-ImsidaThalidomide is an effective chemotherapeutic agent used to achieve remission in multiple myeloma. However, its administration is associated with several adverse effects including venous thromboembolism, while arterial thrombosis has also, although rarely, been described in the literature. We report a case of internal carotid artery occlusion within 1 week of starting thalidomide with prophylactic low molecular weight heparin in a patient who had no other prothrombotic risk factors. It is not known why this complication occurs despite the administration of anticoagulant prophylaxis. The role of factor VIII, von Willebrand factor antigen levels and fibrinogen in multiple myeloma patients should be studied in order to determine if these factors should be targeted in future prophylactic treatment.http://ejcrim.com/index.php/EJCRIM/article/view/410Multiple myelomathalidomidearterial thrombosiscerebrovascular accident. |
| spellingShingle | Maria Angela Grima David James Camilleri A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma European Journal of Case Reports in Internal Medicine Multiple myeloma thalidomide arterial thrombosis cerebrovascular accident. |
| title | A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma |
| title_full | A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma |
| title_fullStr | A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma |
| title_full_unstemmed | A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma |
| title_short | A Case of Internal Carotid Artery Thrombosis associated with Thalidomide Administration in Multiple Myeloma |
| title_sort | case of internal carotid artery thrombosis associated with thalidomide administration in multiple myeloma |
| topic | Multiple myeloma thalidomide arterial thrombosis cerebrovascular accident. |
| url | http://ejcrim.com/index.php/EJCRIM/article/view/410 |
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