Lobe-specific calcium binding in calmodulin regulates endothelial nitric oxide synthase activation.

Lobe-specific calcium binding in calmodulin regulates endothelial nitric oxide synthase activation.

BACKGROUND: Human endothelial nitric oxide synthase (eNOS) requires calcium-bound calmodulin (CaM) for electron transfer but the detailed mechanism remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Using a series of CaM mutants with E to Q substitution at the four calcium-binding sites, we found that...

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Bibliographic Details
Main Authors: Pei-Rung Wu, Cheng-Chin Kuo, Shaw-Fang Yet, Jun-Yang Liou, Kenneth K Wu, Pei-Feng Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3387242?pdf=render

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