The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K2. Here, we show that sterols sti...

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Bibliographic Details
Main Authors: Marc M Schumacher, Rania Elsabrouty, Joachim Seemann, Youngah Jo, Russell A DeBose-Boyd
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
ER associated degradation
cholesterol metabolism
prenyltransferase
vitamin K
isoprenoid
Online Access:https://elifesciences.org/articles/05560

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