Estrogen Receptor and Vascular Aging
Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menop...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2021.727380/full |
| _version_ | 1819135215272984576 |
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| author | Morgane Davezac Melissa Buscato Rana Zahreddine Patrick Lacolley Daniel Henrion Francoise Lenfant Jean-Francois Arnal Coralie Fontaine |
| author_facet | Morgane Davezac Melissa Buscato Rana Zahreddine Patrick Lacolley Daniel Henrion Francoise Lenfant Jean-Francois Arnal Coralie Fontaine |
| author_sort | Morgane Davezac |
| collection | DOAJ |
| description | Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menopause, but the consequences of their abrupt decline on the cardiovascular risk at menopause remain debated. In this review, we will attempt to summarize the main clinical and experimental studies reporting the protective effects of estrogens against cardiovascular diseases, with a particular focus on atherosclerosis, and the impact of aging and estrogen deprivation on their endothelial actions. The arterial actions of estrogens, but also part of that of androgens through their aromatization into estrogens, are mediated by the estrogen receptor (ER)α and ERβ. ERs belong to the nuclear receptor family and act by transcriptional regulation in the nucleus, but also exert non-genomic/extranuclear actions. Beside the decline of estrogens at menopause, abnormalities in the expression and/or function of ERs in the tissues, and particularly in arteries, could contribute to the failure of classic estrogens to protect arteries during aging. Finally, we will discuss how recent insights in the mechanisms of action of ERα could contribute to optimize the hormonal treatment of the menopause. |
| first_indexed | 2024-12-22T10:15:32Z |
| format | Article |
| id | doaj.art-c328f7fd327746b8afe21826fec31c26 |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-12-22T10:15:32Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-c328f7fd327746b8afe21826fec31c262022-12-21T18:29:44ZengFrontiers Media S.A.Frontiers in Aging2673-62172021-09-01210.3389/fragi.2021.727380727380Estrogen Receptor and Vascular AgingMorgane Davezac0Melissa Buscato1Rana Zahreddine2Patrick Lacolley3Daniel Henrion4Francoise Lenfant5Jean-Francois Arnal6Coralie Fontaine7INSERM-UPS UMR U1297, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, FranceINSERM-UPS UMR U1297, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, FranceINSERM-UPS UMR U1297, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, FranceINSERM, UMR_S 1116, DCAC Institute, Université de Lorraine, Vandœuvre-lès-Nancy, FranceINSERM U1083 CNRS UMR 6015, CHU, MITOVASC Institute and CARFI Facility, Université d’Angers, Angers, FranceINSERM-UPS UMR U1297, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, FranceINSERM-UPS UMR U1297, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, FranceINSERM-UPS UMR U1297, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, FranceCardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menopause, but the consequences of their abrupt decline on the cardiovascular risk at menopause remain debated. In this review, we will attempt to summarize the main clinical and experimental studies reporting the protective effects of estrogens against cardiovascular diseases, with a particular focus on atherosclerosis, and the impact of aging and estrogen deprivation on their endothelial actions. The arterial actions of estrogens, but also part of that of androgens through their aromatization into estrogens, are mediated by the estrogen receptor (ER)α and ERβ. ERs belong to the nuclear receptor family and act by transcriptional regulation in the nucleus, but also exert non-genomic/extranuclear actions. Beside the decline of estrogens at menopause, abnormalities in the expression and/or function of ERs in the tissues, and particularly in arteries, could contribute to the failure of classic estrogens to protect arteries during aging. Finally, we will discuss how recent insights in the mechanisms of action of ERα could contribute to optimize the hormonal treatment of the menopause.https://www.frontiersin.org/articles/10.3389/fragi.2021.727380/fullestradiolestrogen receptormenopauseatherosclerosisendotheliumvascular aging |
| spellingShingle | Morgane Davezac Melissa Buscato Rana Zahreddine Patrick Lacolley Daniel Henrion Francoise Lenfant Jean-Francois Arnal Coralie Fontaine Estrogen Receptor and Vascular Aging Frontiers in Aging estradiol estrogen receptor menopause atherosclerosis endothelium vascular aging |
| title | Estrogen Receptor and Vascular Aging |
| title_full | Estrogen Receptor and Vascular Aging |
| title_fullStr | Estrogen Receptor and Vascular Aging |
| title_full_unstemmed | Estrogen Receptor and Vascular Aging |
| title_short | Estrogen Receptor and Vascular Aging |
| title_sort | estrogen receptor and vascular aging |
| topic | estradiol estrogen receptor menopause atherosclerosis endothelium vascular aging |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2021.727380/full |
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