Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection.
Intracellular pathogens are capable of inducing vigorous CD8+ T cell responses. However, we do not entirely understand the factors driving the generation of large pools of highly protective memory CD8+ T cells. Here, we studied the generation of endogenous ovalbumin-specific memory CD8+ T cells foll...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4148391?pdf=render |
| _version_ | 1819148994300870656 |
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| author | Julianne M Zickovich Susan I Meyer Hideo Yagita Joshua J Obar |
| author_facet | Julianne M Zickovich Susan I Meyer Hideo Yagita Joshua J Obar |
| author_sort | Julianne M Zickovich |
| collection | DOAJ |
| description | Intracellular pathogens are capable of inducing vigorous CD8+ T cell responses. However, we do not entirely understand the factors driving the generation of large pools of highly protective memory CD8+ T cells. Here, we studied the generation of endogenous ovalbumin-specific memory CD8+ T cells following infection with recombinant vesicular stomatitis virus (VSV) and Listeria monocytogenes (LM). VSV infection resulted in the generation of a large ovalbumin-specific memory CD8+ T cell population, which provided minimal protective immunity that waned with time. In contrast, the CD8+ T cell population of LM-ova provided protective immunity and remained stable with time. Agonistic CD40 stimulation during CD8+ T cell priming in response to VSV infection enabled the resultant memory CD8+ T cell population to provide strong protective immunity against secondary infection. Enhanced protective immunity by agonistic anti-CD40 was dependent on CD70. Agonistic anti-CD40 not only enhanced the size of the resultant memory CD8+ T cell population, but enhanced their polyfunctionality and sensitivity to antigen. Our data suggest that immunomodulation of CD40 signaling may be a key adjuvant to enhance CD8+ T cell response during development of VSV vaccine strategies. |
| first_indexed | 2024-12-22T13:54:33Z |
| format | Article |
| id | doaj.art-c32947947d38400ba60f528da56844c7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T13:54:33Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c32947947d38400ba60f528da56844c72022-12-21T18:23:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10606010.1371/journal.pone.0106060Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection.Julianne M ZickovichSusan I MeyerHideo YagitaJoshua J ObarIntracellular pathogens are capable of inducing vigorous CD8+ T cell responses. However, we do not entirely understand the factors driving the generation of large pools of highly protective memory CD8+ T cells. Here, we studied the generation of endogenous ovalbumin-specific memory CD8+ T cells following infection with recombinant vesicular stomatitis virus (VSV) and Listeria monocytogenes (LM). VSV infection resulted in the generation of a large ovalbumin-specific memory CD8+ T cell population, which provided minimal protective immunity that waned with time. In contrast, the CD8+ T cell population of LM-ova provided protective immunity and remained stable with time. Agonistic CD40 stimulation during CD8+ T cell priming in response to VSV infection enabled the resultant memory CD8+ T cell population to provide strong protective immunity against secondary infection. Enhanced protective immunity by agonistic anti-CD40 was dependent on CD70. Agonistic anti-CD40 not only enhanced the size of the resultant memory CD8+ T cell population, but enhanced their polyfunctionality and sensitivity to antigen. Our data suggest that immunomodulation of CD40 signaling may be a key adjuvant to enhance CD8+ T cell response during development of VSV vaccine strategies.http://europepmc.org/articles/PMC4148391?pdf=render |
| spellingShingle | Julianne M Zickovich Susan I Meyer Hideo Yagita Joshua J Obar Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection. PLoS ONE |
| title | Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection. |
| title_full | Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection. |
| title_fullStr | Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection. |
| title_full_unstemmed | Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection. |
| title_short | Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection. |
| title_sort | agonistic anti cd40 enhances the cd8 t cell response during vesicular stomatitis virus infection |
| url | http://europepmc.org/articles/PMC4148391?pdf=render |
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