Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1

Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1

Abstract Background Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal (BET) proteins are required for the expression of a subset of NF-κB-in...

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Bibliographic Details
Main Authors: Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort, Ian M. Adcock
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Respiratory Research
Subjects:
Bromodomain and extra‐terminal proteins
Human pulmonary microvascular endothelial cells
Human pulmonary artery smooth muscle cells
Inflammation
Pulmonary arterial hypertension
Online Access:https://doi.org/10.1186/s12931-023-02499-y

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