Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat
Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n = 70) of 14-year olds with a history of cannabis use to a group (n = 70) of never-using controls matc...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-12-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929315000857 |
| _version_ | 1811268319505809408 |
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| author | Philip A. Spechler Catherine A. Orr Bader Chaarani Kees-Jan Kan Scott Mackey Aaron Morton Mitchell P. Snowe Kelsey E. Hudson Robert R. Althoff Stephen T. Higgins Anna Cattrell Herta Flor Frauke Nees Tobias Banaschewski Arun L.W. Bokde Robert Whelan Christian Büchel Uli Bromberg Patricia Conrod Vincent Frouin Dimitri Papadopoulos Jurgen Gallinat Andreas Heinz Henrik Walter Bernd Ittermann Penny Gowland Tomáš Paus Luise Poustka Jean-Luc Martinot Eric Artiges Michael N. Smolka Gunter Schumann Hugh Garavan |
| author_facet | Philip A. Spechler Catherine A. Orr Bader Chaarani Kees-Jan Kan Scott Mackey Aaron Morton Mitchell P. Snowe Kelsey E. Hudson Robert R. Althoff Stephen T. Higgins Anna Cattrell Herta Flor Frauke Nees Tobias Banaschewski Arun L.W. Bokde Robert Whelan Christian Büchel Uli Bromberg Patricia Conrod Vincent Frouin Dimitri Papadopoulos Jurgen Gallinat Andreas Heinz Henrik Walter Bernd Ittermann Penny Gowland Tomáš Paus Luise Poustka Jean-Luc Martinot Eric Artiges Michael N. Smolka Gunter Schumann Hugh Garavan |
| author_sort | Philip A. Spechler |
| collection | DOAJ |
| description | Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n = 70) of 14-year olds with a history of cannabis use to a group (n = 70) of never-using controls matched on numerous characteristics including IQ, SES, alcohol and cigarette use. The task contained short movies displaying angry and neutral faces. Results indicated that cannabis users had greater reactivity in the bilateral amygdalae to angry faces than neutral faces, an effect that was not observed in their abstinent peers. In contrast, activity levels in the cannabis users in cortical areas including the right temporal-parietal junction and bilateral dorsolateral prefrontal cortex did not discriminate between the two face conditions, but did differ in controls. Results did not change after excluding subjects with any psychiatric symptomology. Given the high density of cannabinoid receptors in the amygdala, our findings suggest cannabis use in early adolescence is associated with hypersensitivity to signals of threat. Hypersensitivity to negative affect in adolescence may place the subject at-risk for mood disorders in adulthood. |
| first_indexed | 2024-04-12T21:19:34Z |
| format | Article |
| id | doaj.art-c32a69a5b2a3434886ba302297e72fb8 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-04-12T21:19:34Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-c32a69a5b2a3434886ba302297e72fb82022-12-22T03:16:20ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072015-12-0116C637010.1016/j.dcn.2015.08.007Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threatPhilip A. Spechler0Catherine A. Orr1Bader Chaarani2Kees-Jan Kan3Scott Mackey4Aaron Morton5Mitchell P. Snowe6Kelsey E. Hudson7Robert R. Althoff8Stephen T. Higgins9Anna Cattrell10Herta Flor11Frauke Nees12Tobias Banaschewski13Arun L.W. Bokde14Robert Whelan15Christian Büchel16Uli Bromberg17Patricia Conrod18Vincent Frouin19Dimitri Papadopoulos20Jurgen Gallinat21Andreas Heinz22Henrik Walter23Bernd Ittermann24Penny Gowland25Tomáš Paus26Luise Poustka27Jean-Luc Martinot28Eric Artiges29Michael N. Smolka30Gunter Schumann31Hugh Garavan32Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center for Children, Youth, and Families, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesInstitute of Psychiatry, King's College London, United KingdomDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GermanyDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, IrelandDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GermanyDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, IrelandDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, IrelandUniversity Medical Centre Hamburg-Eppendorf, Haus S10, Martinistr. 52, Hamburg, GermanyDepartment of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, CanadaInstitute of Psychiatry, King's College London, United KingdomNeurospin, Commissariat à l’Energie Atomique, CEA-Saclay Center, Paris, FranceDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistrasse 52, 20246 Hamburg, GermanyDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistrasse 52, 20246 Hamburg, GermanyDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, GermanyPhysikalisch-Technische Bundesanstalt, Abbestr. 2-12, Berlin, GermanyPhysikalisch-Technische Bundesanstalt, Abbestr. 2-12, Berlin, GermanySchool of Psychology, University of Nottingham, University Park, Nottingham, United KingdomRotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario M6A 2E1, CanadaDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, IrelandInstitut National de la Sante et de la Recherche Medicale, INSERM CEAUnit1000, “Imaging & Psychiatry”, University Paris Sud, 91400 Orsay, FranceRotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario M6A 2E1, CanadaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GermanyInstitute of Psychiatry, King's College London, United KingdomVermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, United StatesCannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n = 70) of 14-year olds with a history of cannabis use to a group (n = 70) of never-using controls matched on numerous characteristics including IQ, SES, alcohol and cigarette use. The task contained short movies displaying angry and neutral faces. Results indicated that cannabis users had greater reactivity in the bilateral amygdalae to angry faces than neutral faces, an effect that was not observed in their abstinent peers. In contrast, activity levels in the cannabis users in cortical areas including the right temporal-parietal junction and bilateral dorsolateral prefrontal cortex did not discriminate between the two face conditions, but did differ in controls. Results did not change after excluding subjects with any psychiatric symptomology. Given the high density of cannabinoid receptors in the amygdala, our findings suggest cannabis use in early adolescence is associated with hypersensitivity to signals of threat. Hypersensitivity to negative affect in adolescence may place the subject at-risk for mood disorders in adulthood.http://www.sciencedirect.com/science/article/pii/S1878929315000857CannabisAdolescenceFace processingfMRIAmygdalaEmotionFaces |
| spellingShingle | Philip A. Spechler Catherine A. Orr Bader Chaarani Kees-Jan Kan Scott Mackey Aaron Morton Mitchell P. Snowe Kelsey E. Hudson Robert R. Althoff Stephen T. Higgins Anna Cattrell Herta Flor Frauke Nees Tobias Banaschewski Arun L.W. Bokde Robert Whelan Christian Büchel Uli Bromberg Patricia Conrod Vincent Frouin Dimitri Papadopoulos Jurgen Gallinat Andreas Heinz Henrik Walter Bernd Ittermann Penny Gowland Tomáš Paus Luise Poustka Jean-Luc Martinot Eric Artiges Michael N. Smolka Gunter Schumann Hugh Garavan Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat Developmental Cognitive Neuroscience Cannabis Adolescence Face processing fMRI Amygdala Emotion Faces |
| title | Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat |
| title_full | Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat |
| title_fullStr | Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat |
| title_full_unstemmed | Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat |
| title_short | Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat |
| title_sort | cannabis use in early adolescence evidence of amygdala hypersensitivity to signals of threat |
| topic | Cannabis Adolescence Face processing fMRI Amygdala Emotion Faces |
| url | http://www.sciencedirect.com/science/article/pii/S1878929315000857 |
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