Sleep–Wake Cycle in Young and Older Mice
Sleep plays a key role in multiple cognitive functions and sleep pattern changes with aging. Human studies revealed that aging decreases sleep efficiency and reduces the total sleep time, the time spent in slow-wave sleep (SWS), and the delta power (1–4 Hz) during sleep; however, some studies of sle...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnsys.2019.00051/full |
| _version_ | 1818032180134150144 |
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| author | Sara Soltani Sara Soltani Sylvain Chauvette Olga Bukhtiyarova Olga Bukhtiyarova Jean-Marc Lina Jean-Marc Lina Jonathan Dubé Jonathan Dubé Josée Seigneur Julie Carrier Julie Carrier Igor Timofeev Igor Timofeev |
| author_facet | Sara Soltani Sara Soltani Sylvain Chauvette Olga Bukhtiyarova Olga Bukhtiyarova Jean-Marc Lina Jean-Marc Lina Jonathan Dubé Jonathan Dubé Josée Seigneur Julie Carrier Julie Carrier Igor Timofeev Igor Timofeev |
| author_sort | Sara Soltani |
| collection | DOAJ |
| description | Sleep plays a key role in multiple cognitive functions and sleep pattern changes with aging. Human studies revealed that aging decreases sleep efficiency and reduces the total sleep time, the time spent in slow-wave sleep (SWS), and the delta power (1–4 Hz) during sleep; however, some studies of sleep and aging in mice reported opposing results. The aim of our work is to estimate how features of sleep–wake state in mice during aging could correspond to age-dependent changes observed in human. In this study, we investigated the sleep/wake cycle in young (3 months old) and older (12 months old) C57BL/6 mice using local-field potentials (LFPs). We found that older adult mice sleep more than young ones but only during the dark phase of sleep-wake cycle. Sleep fragmentation and sleep during the active phase (dark phase of cycle), homologous to naps, were higher in older mice. Older mice show a higher delta power in frontal cortex, which was accompanied with similar trend for age differences in slow wave density. We also investigated regional specificity of sleep–wake electrographic activities and found that globally posterior regions of the cortex show more rapid eye movement (REM) sleep whereas somatosensory cortex displays more often SWS patterns. Our results indicate that the effects of aging on the sleep–wake activities in mice occur mainly during the dark phase and the electrode location strongly influence the state detection. Despite some differences in sleep–wake cycle during aging between human and mice, some features of mice sleep share similarity with human sleep during aging. |
| first_indexed | 2024-12-10T06:03:16Z |
| format | Article |
| id | doaj.art-c32bf8b9e6cf45a6b4f8efc592bd73e3 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-10T06:03:16Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-c32bf8b9e6cf45a6b4f8efc592bd73e32022-12-22T01:59:45ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372019-09-011310.3389/fnsys.2019.00051471051Sleep–Wake Cycle in Young and Older MiceSara Soltani0Sara Soltani1Sylvain Chauvette2Olga Bukhtiyarova3Olga Bukhtiyarova4Jean-Marc Lina5Jean-Marc Lina6Jonathan Dubé7Jonathan Dubé8Josée Seigneur9Julie Carrier10Julie Carrier11Igor Timofeev12Igor Timofeev13Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Québec, QC, CanadaCERVO Brain Research Centre, Québec, QC, CanadaCERVO Brain Research Centre, Québec, QC, CanadaDepartment of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Québec, QC, CanadaCERVO Brain Research Centre, Québec, QC, CanadaCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l’Ile de Montréal, Montreal, QC, CanadaÉcole de Technologie Supérieure, Montreal, QC, CanadaCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l’Ile de Montréal, Montreal, QC, CanadaDepartment of Psychology, Université de Montréal, Montreal, QC, CanadaCERVO Brain Research Centre, Québec, QC, CanadaCenter for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l’Ile de Montréal, Montreal, QC, CanadaDepartment of Psychology, Université de Montréal, Montreal, QC, CanadaDepartment of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Québec, QC, CanadaCERVO Brain Research Centre, Québec, QC, CanadaSleep plays a key role in multiple cognitive functions and sleep pattern changes with aging. Human studies revealed that aging decreases sleep efficiency and reduces the total sleep time, the time spent in slow-wave sleep (SWS), and the delta power (1–4 Hz) during sleep; however, some studies of sleep and aging in mice reported opposing results. The aim of our work is to estimate how features of sleep–wake state in mice during aging could correspond to age-dependent changes observed in human. In this study, we investigated the sleep/wake cycle in young (3 months old) and older (12 months old) C57BL/6 mice using local-field potentials (LFPs). We found that older adult mice sleep more than young ones but only during the dark phase of sleep-wake cycle. Sleep fragmentation and sleep during the active phase (dark phase of cycle), homologous to naps, were higher in older mice. Older mice show a higher delta power in frontal cortex, which was accompanied with similar trend for age differences in slow wave density. We also investigated regional specificity of sleep–wake electrographic activities and found that globally posterior regions of the cortex show more rapid eye movement (REM) sleep whereas somatosensory cortex displays more often SWS patterns. Our results indicate that the effects of aging on the sleep–wake activities in mice occur mainly during the dark phase and the electrode location strongly influence the state detection. Despite some differences in sleep–wake cycle during aging between human and mice, some features of mice sleep share similarity with human sleep during aging.https://www.frontiersin.org/article/10.3389/fnsys.2019.00051/fullsleep–wake cycleLFPdelta powerSWSREMwake |
| spellingShingle | Sara Soltani Sara Soltani Sylvain Chauvette Olga Bukhtiyarova Olga Bukhtiyarova Jean-Marc Lina Jean-Marc Lina Jonathan Dubé Jonathan Dubé Josée Seigneur Julie Carrier Julie Carrier Igor Timofeev Igor Timofeev Sleep–Wake Cycle in Young and Older Mice Frontiers in Systems Neuroscience sleep–wake cycle LFP delta power SWS REM wake |
| title | Sleep–Wake Cycle in Young and Older Mice |
| title_full | Sleep–Wake Cycle in Young and Older Mice |
| title_fullStr | Sleep–Wake Cycle in Young and Older Mice |
| title_full_unstemmed | Sleep–Wake Cycle in Young and Older Mice |
| title_short | Sleep–Wake Cycle in Young and Older Mice |
| title_sort | sleep wake cycle in young and older mice |
| topic | sleep–wake cycle LFP delta power SWS REM wake |
| url | https://www.frontiersin.org/article/10.3389/fnsys.2019.00051/full |
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