Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing Country
Objective: To assess the effectiveness of Quad test in the detection of Down syndrome (DS) in routine practice among a large-scale population and to compare the effectiveness of Quad test based on the Western reference model (WM) and that based on Thai reference model (TM).Methods: Quad test was per...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
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| Series: | International Journal of Public Health |
| Subjects: | |
| Online Access: | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605441/full |
| _version_ | 1797851671017029632 |
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| author | Nitchanut Chaipongpun Chanane Wanapirak Supatra Sirichotiyakul Fuanglada Tongprasert Kasemsri Srisupundit Suchaya Luewan Kuntharee Traisrisilp Phudit Jatavan Sirinart Sirilert Theera Tongsong |
| author_facet | Nitchanut Chaipongpun Chanane Wanapirak Supatra Sirichotiyakul Fuanglada Tongprasert Kasemsri Srisupundit Suchaya Luewan Kuntharee Traisrisilp Phudit Jatavan Sirinart Sirilert Theera Tongsong |
| author_sort | Nitchanut Chaipongpun |
| collection | DOAJ |
| description | Objective: To assess the effectiveness of Quad test in the detection of Down syndrome (DS) in routine practice among a large-scale population and to compare the effectiveness of Quad test based on the Western reference model (WM) and that based on Thai reference model (TM).Methods: Quad test was performed on 42,769 pregnancies at 14–21 weeks. The fetal risk of DS derived from Quad test was automatically computed based on WM and used in evaluating the effectiveness. Also, the fetal risk was calculated based on the TM.Results: Of 39,740 women with complete follow-ups including 74 fetuses with DS, with WM, the detection and false positive rates were 81.1% and 7.2%, respectively, whereas the detection and false positive rates with TM were 87.8%, and 6.8%, respectively. According to ROC curves, the performance of Quad test based on TM was slightly but significantly better than that based on WM (AUC of 0.959 vs. 0.940, p = 0.001).Conclusion: Quad test is highly effective in service settings and suitable for developing countries and the effectiveness is even higher when based on ethnicity-specific reference model. |
| first_indexed | 2024-04-09T19:21:34Z |
| format | Article |
| id | doaj.art-c32c990ce30d49eead4f4a055ae35f32 |
| institution | Directory Open Access Journal |
| issn | 1661-8564 |
| language | English |
| last_indexed | 2024-04-09T19:21:34Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | International Journal of Public Health |
| spelling | doaj.art-c32c990ce30d49eead4f4a055ae35f322023-04-05T12:35:01ZengFrontiers Media S.A.International Journal of Public Health1661-85642023-04-016810.3389/ijph.2023.16054411605441Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing CountryNitchanut ChaipongpunChanane WanapirakSupatra SirichotiyakulFuanglada TongprasertKasemsri SrisupunditSuchaya LuewanKuntharee TraisrisilpPhudit JatavanSirinart SirilertTheera TongsongObjective: To assess the effectiveness of Quad test in the detection of Down syndrome (DS) in routine practice among a large-scale population and to compare the effectiveness of Quad test based on the Western reference model (WM) and that based on Thai reference model (TM).Methods: Quad test was performed on 42,769 pregnancies at 14–21 weeks. The fetal risk of DS derived from Quad test was automatically computed based on WM and used in evaluating the effectiveness. Also, the fetal risk was calculated based on the TM.Results: Of 39,740 women with complete follow-ups including 74 fetuses with DS, with WM, the detection and false positive rates were 81.1% and 7.2%, respectively, whereas the detection and false positive rates with TM were 87.8%, and 6.8%, respectively. According to ROC curves, the performance of Quad test based on TM was slightly but significantly better than that based on WM (AUC of 0.959 vs. 0.940, p = 0.001).Conclusion: Quad test is highly effective in service settings and suitable for developing countries and the effectiveness is even higher when based on ethnicity-specific reference model.https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605441/fulldeveloping countrydown syndromeprenatal diagnosisprenatal screeningquadruple test |
| spellingShingle | Nitchanut Chaipongpun Chanane Wanapirak Supatra Sirichotiyakul Fuanglada Tongprasert Kasemsri Srisupundit Suchaya Luewan Kuntharee Traisrisilp Phudit Jatavan Sirinart Sirilert Theera Tongsong Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing Country International Journal of Public Health developing country down syndrome prenatal diagnosis prenatal screening quadruple test |
| title | Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing Country |
| title_full | Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing Country |
| title_fullStr | Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing Country |
| title_full_unstemmed | Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing Country |
| title_short | Performance of Serum Quad Test in Screening for Fetal Down Syndrome in a Large-Scale Unselected Population in a Developing Country |
| title_sort | performance of serum quad test in screening for fetal down syndrome in a large scale unselected population in a developing country |
| topic | developing country down syndrome prenatal diagnosis prenatal screening quadruple test |
| url | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605441/full |
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