Metabolic plasticity of T cell fate decision
Abstract. The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T cells. Upon antigen exposure, T cells undergo metabolic reprogramming, leading to the development of functional effectors or memory populations. However, within the tumor microenvironment (TM...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2024-04-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002989 |
| _version_ | 1797224424213053440 |
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| author | Xiaoli Pan Jiajia Wang Lianjun Zhang Guideng Li Bo Huang Jing Ni Xuehong Zhang |
| author_facet | Xiaoli Pan Jiajia Wang Lianjun Zhang Guideng Li Bo Huang Jing Ni Xuehong Zhang |
| author_sort | Xiaoli Pan |
| collection | DOAJ |
| description | Abstract. The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T cells. Upon antigen exposure, T cells undergo metabolic reprogramming, leading to the development of functional effectors or memory populations. However, within the tumor microenvironment (TME), metabolic stress impairs CD8+ T cell anti-tumor immunity, resulting in exhausted differentiation. Recent studies suggested that targeting T cell metabolism could offer promising therapeutic opportunities to enhance T cell immunotherapy. In this review, we provide a comprehensive summary of the intrinsic and extrinsic factors necessary for metabolic reprogramming during the development of effector and memory T cells in response to acute and chronic inflammatory conditions. Furthermore, we delved into the different metabolic switches that occur during T cell exhaustion, exploring how prolonged metabolic stress within the TME triggers alterations in cellular metabolism and the epigenetic landscape that contribute to T cell exhaustion, ultimately leading to a persistently exhausted state. Understanding the intricate relationship between T cell metabolism and cancer immunotherapy can lead to the development of novel approaches to improve the efficacy of T cell-based treatments against cancer. |
| first_indexed | 2024-04-24T13:52:54Z |
| format | Article |
| id | doaj.art-c32cfccebde44a73bb0cf75c1f108b6d |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-04-24T13:52:54Z |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-c32cfccebde44a73bb0cf75c1f108b6d2024-04-04T03:29:11ZengWolters KluwerChinese Medical Journal0366-69992542-56412024-04-01137776277510.1097/CM9.0000000000002989202404050-00002Metabolic plasticity of T cell fate decisionXiaoli Pan0Jiajia Wang1Lianjun Zhang2Guideng Li3Bo Huang4Jing NiXuehong Zhang1 National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China1 National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China1 National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China1 National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China3 Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing 100005, ChinaAbstract. The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T cells. Upon antigen exposure, T cells undergo metabolic reprogramming, leading to the development of functional effectors or memory populations. However, within the tumor microenvironment (TME), metabolic stress impairs CD8+ T cell anti-tumor immunity, resulting in exhausted differentiation. Recent studies suggested that targeting T cell metabolism could offer promising therapeutic opportunities to enhance T cell immunotherapy. In this review, we provide a comprehensive summary of the intrinsic and extrinsic factors necessary for metabolic reprogramming during the development of effector and memory T cells in response to acute and chronic inflammatory conditions. Furthermore, we delved into the different metabolic switches that occur during T cell exhaustion, exploring how prolonged metabolic stress within the TME triggers alterations in cellular metabolism and the epigenetic landscape that contribute to T cell exhaustion, ultimately leading to a persistently exhausted state. Understanding the intricate relationship between T cell metabolism and cancer immunotherapy can lead to the development of novel approaches to improve the efficacy of T cell-based treatments against cancer.http://journals.lww.com/10.1097/CM9.0000000000002989 |
| spellingShingle | Xiaoli Pan Jiajia Wang Lianjun Zhang Guideng Li Bo Huang Jing Ni Xuehong Zhang Metabolic plasticity of T cell fate decision Chinese Medical Journal |
| title | Metabolic plasticity of T cell fate decision |
| title_full | Metabolic plasticity of T cell fate decision |
| title_fullStr | Metabolic plasticity of T cell fate decision |
| title_full_unstemmed | Metabolic plasticity of T cell fate decision |
| title_short | Metabolic plasticity of T cell fate decision |
| title_sort | metabolic plasticity of t cell fate decision |
| url | http://journals.lww.com/10.1097/CM9.0000000000002989 |
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