Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration
An ideal fixation system for guided bone (GBR) regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation, complete resorption when no longer needed, complete replacement by bone, as well as be biocompatible and have a good clinical manageab...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-08-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21005028 |
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| author | Željka Perić Kačarević Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch Dávid Botond Hangyási Balint Molnar Till Kämmerer Bernhard Hesse Emely Bortel Marco Bartosch Frank Witte |
| author_facet | Željka Perić Kačarević Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch Dávid Botond Hangyási Balint Molnar Till Kämmerer Bernhard Hesse Emely Bortel Marco Bartosch Frank Witte |
| author_sort | Željka Perić Kačarević |
| collection | DOAJ |
| description | An ideal fixation system for guided bone (GBR) regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation, complete resorption when no longer needed, complete replacement by bone, as well as be biocompatible and have a good clinical manageability. For the first time, a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these criteria. Adequate mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable device. Results demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of degradation. Biocompatibility of the magnesium fixation screw was demonstrated in several in vitro and in vivo tests. Degradation of the magnesium screw was investigated in in vitro and in vivo tests, where it was found that the screw is resorbed slowly and completely after 52 weeks, providing adequate fixation in the early critical healing phase. Overall, the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration (GBR) surgeries. |
| first_indexed | 2024-04-13T01:11:27Z |
| format | Article |
| id | doaj.art-c32da69e54e74c8892571d2d26ce3740 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:36:03Z |
| publishDate | 2022-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-c32da69e54e74c8892571d2d26ce37402024-04-16T17:16:33ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-08-01141530Biodegradable magnesium fixation screw for barrier membranes used in guided bone regenerationŽeljka Perić Kačarević0Patrick Rider1Akiva Elad2Drazen Tadic3Daniel Rothamel4Gerrit Sauer5Fabien Bornert6Peter Windisch7Dávid Botond Hangyási8Balint Molnar9Till Kämmerer10Bernhard Hesse11Emely Bortel12Marco Bartosch13Frank Witte14Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, Osijek, 31000, Croatia; Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité – Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, 14197, Berlin, Germany; Botiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, GermanyDepartment of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité – Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, 14197, Berlin, Germany; Botiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, GermanyBotiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, GermanyBotiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, GermanyCMF Surgery, Johannes BLA Hospital, Mönchengladbach, GermanyCMF Surgery, Johannes BLA Hospital, Mönchengladbach, GermanyDental Clinic, University of Strasbourg, FranceDepartment of Periodontology, Semmelweis University, Budapest, HungaryDepartment of Periodontology, Semmelweis University, Budapest, HungaryDepartment of Periodontology, Semmelweis University, Budapest, HungaryUniversity Hospital Munich, Department of Dermatology and Allergy, Frauenlobstr. 9-11, 80337, Munich, GermanyXploraytion GmbH, Bismarkstrasse 11, Berlin, GermanyXploraytion GmbH, Bismarkstrasse 11, Berlin, GermanyBiotrics Bioimplants AG, Ullsteinstrasse 108, 12109, Berlin, GermanyDepartment of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité – Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, 14197, Berlin, Germany; Biotrics Bioimplants AG, Ullsteinstrasse 108, 12109, Berlin, Germany; Corresponding author. Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité – Universitätsmedizin Berlin, Assmannshauser Straße 4–6, 14197, Berlin, Germany.An ideal fixation system for guided bone (GBR) regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation, complete resorption when no longer needed, complete replacement by bone, as well as be biocompatible and have a good clinical manageability. For the first time, a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these criteria. Adequate mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable device. Results demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of degradation. Biocompatibility of the magnesium fixation screw was demonstrated in several in vitro and in vivo tests. Degradation of the magnesium screw was investigated in in vitro and in vivo tests, where it was found that the screw is resorbed slowly and completely after 52 weeks, providing adequate fixation in the early critical healing phase. Overall, the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration (GBR) surgeries.http://www.sciencedirect.com/science/article/pii/S2452199X21005028MagnesiumBiodegradableImplantGBRBone healingSoft tissue healing |
| spellingShingle | Željka Perić Kačarević Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch Dávid Botond Hangyási Balint Molnar Till Kämmerer Bernhard Hesse Emely Bortel Marco Bartosch Frank Witte Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration Bioactive Materials Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing |
| title | Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration |
| title_full | Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration |
| title_fullStr | Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration |
| title_full_unstemmed | Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration |
| title_short | Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration |
| title_sort | biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration |
| topic | Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21005028 |
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