Comparative study of pulmonary functions test among different substances abusers
Abstract Background Substance use is a problem that affects people all over the world and is prevalent in different age groups. The lungs in particular, with their unique exposure to the environment and the bloodstream, are vulnerable to damage from substance use and can affect lung function. Effort...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-023-02760-6 |
| _version_ | 1797454110340939776 |
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| author | Hana Salah Musa Mohamed Ibrahim Abdelrhim Ali |
| author_facet | Hana Salah Musa Mohamed Ibrahim Abdelrhim Ali |
| author_sort | Hana Salah Musa Mohamed |
| collection | DOAJ |
| description | Abstract Background Substance use is a problem that affects people all over the world and is prevalent in different age groups. The lungs in particular, with their unique exposure to the environment and the bloodstream, are vulnerable to damage from substance use and can affect lung function. Efforts have generally focused on cigarettes, while there is little research on different substances of use. The study aimed to detect changes in pulmonary function tests in different substance users. Methods An analytical cross-sectional study was carried out among different substance users at the Abdalaal Elidridi Psychiatric Hospital. A total of 60 adults were included: 16 cannabis users, 16 heroin users, 16 methamphetamine users, and 12 alcohol users. Participants used only one substance. Height and weight were measured, and BMI was calculated. For each participant, pulmonary function tests (PFTs) including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC ratio and peak expiratory flow rate (PEFR) were measured using an electronic spirometer, and the results were compared with normal reference values for Sudanese subjects matched for age, sex, and height. Results A high prevalence of lung function abnormalities (100.0%) is seen in all abusers. Obstructive lung disease is found in 80.0% of patients, and restrictive lung disease is found in 20.0% of cases. The measured FEV1/FVC ratio in different substance groups was lower than the expected normal values of (88.2 ± 2.9%). The mean FEV1/FVC ratio of alcohol was (83.6 ± 7.6%), for heroin, it was (77.3 ± 15.8%), for methamphetamine, it was (77.7 ± 17.8%) and for cannabis, it was (71.03 ± 11.3%), the latter was significantly lower than the other two groups (P < 0.001). Duration of substance use was inversely correlated with the FEV1/FVC ratio (r = -0.378, P 0.001), indicating that a longer duration of substance use correlates with lower FEV1/FVC ratios. Conclusions Obstructive lung abnormalities are frequent in substance abusers. All types of substances have a major deleterious effect on PFTs and harm the respiratory system. More action should be taken to address the effects of substances on the lungs. Awareness, early detection, and intervention are essential. |
| first_indexed | 2024-03-09T15:32:31Z |
| format | Article |
| id | doaj.art-c32fde7efdbf40ee978e1e333c1067c2 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-09T15:32:31Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-c32fde7efdbf40ee978e1e333c1067c22023-11-26T12:12:43ZengBMCBMC Pulmonary Medicine1471-24662023-11-012311810.1186/s12890-023-02760-6Comparative study of pulmonary functions test among different substances abusersHana Salah Musa Mohamed0Ibrahim Abdelrhim Ali1Department of Physiology, Faculty of Medicine, The National Ribat UniversityDepartment of Physiology, Faculty of Medicine, The National Ribat UniversityAbstract Background Substance use is a problem that affects people all over the world and is prevalent in different age groups. The lungs in particular, with their unique exposure to the environment and the bloodstream, are vulnerable to damage from substance use and can affect lung function. Efforts have generally focused on cigarettes, while there is little research on different substances of use. The study aimed to detect changes in pulmonary function tests in different substance users. Methods An analytical cross-sectional study was carried out among different substance users at the Abdalaal Elidridi Psychiatric Hospital. A total of 60 adults were included: 16 cannabis users, 16 heroin users, 16 methamphetamine users, and 12 alcohol users. Participants used only one substance. Height and weight were measured, and BMI was calculated. For each participant, pulmonary function tests (PFTs) including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC ratio and peak expiratory flow rate (PEFR) were measured using an electronic spirometer, and the results were compared with normal reference values for Sudanese subjects matched for age, sex, and height. Results A high prevalence of lung function abnormalities (100.0%) is seen in all abusers. Obstructive lung disease is found in 80.0% of patients, and restrictive lung disease is found in 20.0% of cases. The measured FEV1/FVC ratio in different substance groups was lower than the expected normal values of (88.2 ± 2.9%). The mean FEV1/FVC ratio of alcohol was (83.6 ± 7.6%), for heroin, it was (77.3 ± 15.8%), for methamphetamine, it was (77.7 ± 17.8%) and for cannabis, it was (71.03 ± 11.3%), the latter was significantly lower than the other two groups (P < 0.001). Duration of substance use was inversely correlated with the FEV1/FVC ratio (r = -0.378, P 0.001), indicating that a longer duration of substance use correlates with lower FEV1/FVC ratios. Conclusions Obstructive lung abnormalities are frequent in substance abusers. All types of substances have a major deleterious effect on PFTs and harm the respiratory system. More action should be taken to address the effects of substances on the lungs. Awareness, early detection, and intervention are essential.https://doi.org/10.1186/s12890-023-02760-6Pulmonary function testsCannabisHeroinMethamphetamineAlcohol |
| spellingShingle | Hana Salah Musa Mohamed Ibrahim Abdelrhim Ali Comparative study of pulmonary functions test among different substances abusers BMC Pulmonary Medicine Pulmonary function tests Cannabis Heroin Methamphetamine Alcohol |
| title | Comparative study of pulmonary functions test among different substances abusers |
| title_full | Comparative study of pulmonary functions test among different substances abusers |
| title_fullStr | Comparative study of pulmonary functions test among different substances abusers |
| title_full_unstemmed | Comparative study of pulmonary functions test among different substances abusers |
| title_short | Comparative study of pulmonary functions test among different substances abusers |
| title_sort | comparative study of pulmonary functions test among different substances abusers |
| topic | Pulmonary function tests Cannabis Heroin Methamphetamine Alcohol |
| url | https://doi.org/10.1186/s12890-023-02760-6 |
| work_keys_str_mv | AT hanasalahmusamohamed comparativestudyofpulmonaryfunctionstestamongdifferentsubstancesabusers AT ibrahimabdelrhimali comparativestudyofpulmonaryfunctionstestamongdifferentsubstancesabusers |