Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy
Orthopedic delayed and late infections are devastating afflictions for patients who have undergone implantation. Even though versatile antibacterial modification on medical devices brought the hope of eradicating pathogenic bacteria. The synthesis of late-term antibacterial properties with total mor...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523006482 |
| _version_ | 1797671490187952128 |
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| author | Yikai Wang Zhongru Gou Siyuan Ma Zhihui Jin Sen Chen Jia Ye Zhigang Nie Zhihui Wan Chongda Zhang Yuxiao Ye Xiaohua Yu Zhaoming Ye Yijun Ren |
| author_facet | Yikai Wang Zhongru Gou Siyuan Ma Zhihui Jin Sen Chen Jia Ye Zhigang Nie Zhihui Wan Chongda Zhang Yuxiao Ye Xiaohua Yu Zhaoming Ye Yijun Ren |
| author_sort | Yikai Wang |
| collection | DOAJ |
| description | Orthopedic delayed and late infections are devastating afflictions for patients who have undergone implantation. Even though versatile antibacterial modification on medical devices brought the hope of eradicating pathogenic bacteria. The synthesis of late-term antibacterial properties with total morphosynthesis on medical devices nonetheless remains an elusive goal. Herein, we utilize a mineralized strategy coupled with ion exchange to generate lamellar-type magnesium calcium phosphate thin films with a three-step pathway: Construction of nanofiber porous structure on the substrate as ions reservoir, incorporation of magnesium substitutional transition sodium titanate layer, and mineralization of a lamellar calcium phosphate coating. Synthetic lamellar coatings exhibit excellent osteointegration effects in infectious scenarios. More importantly, the underlying transition layer can blow up the possible delayed infection like a landmine after the upper calcium phosphate coating is degraded under the physiological environment. This work highlights the pivotal role of the magnesium ions in mediating the growth of the total morphosynthesis of calcium phosphate coating and the underlying magnesium titanate layer in ensuring the possibility to eliminate delayed infections under time-dependent degradation. |
| first_indexed | 2024-03-11T21:16:17Z |
| format | Article |
| id | doaj.art-c330caa9a8a94d0e9912390a80a5013c |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T21:16:17Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-c330caa9a8a94d0e9912390a80a5013c2023-09-29T04:43:28ZengElsevierMaterials & Design0264-12752023-09-01233112233Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategyYikai Wang0Zhongru Gou1Siyuan Ma2Zhihui Jin3Sen Chen4Jia Ye5Zhigang Nie6Zhihui Wan7Chongda Zhang8Yuxiao Ye9Xiaohua Yu10Zhaoming Ye11Yijun Ren12Microorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR ChinaBio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, PR ChinaMicroorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR ChinaMicroorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR ChinaMicroorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR ChinaMicroorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR ChinaMicroorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR ChinaMicroorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR ChinaNew York University Medical Center, New York University, New York 10016, USASchool of Material Science and Engineering, University of New South Wales, Sydney 2052, AustraliaDepartment of Orthopedics, Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Corresponding authors at: Department of Orthopedics, Renmin Hospital of Wuhan University, 238# Jiefang Road, Wuhan 430060, PR China (Y. Ren); Department of Orthopedics, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou 310000, P.R. China (X. Yu and Z. Ye).Department of Orthopedics, Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Corresponding authors at: Department of Orthopedics, Renmin Hospital of Wuhan University, 238# Jiefang Road, Wuhan 430060, PR China (Y. Ren); Department of Orthopedics, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou 310000, P.R. China (X. Yu and Z. Ye).Microorthopedics/Trauma Center, Department of Orthopedics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR China; Corresponding authors at: Department of Orthopedics, Renmin Hospital of Wuhan University, 238# Jiefang Road, Wuhan 430060, PR China (Y. Ren); Department of Orthopedics, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou 310000, P.R. China (X. Yu and Z. Ye).Orthopedic delayed and late infections are devastating afflictions for patients who have undergone implantation. Even though versatile antibacterial modification on medical devices brought the hope of eradicating pathogenic bacteria. The synthesis of late-term antibacterial properties with total morphosynthesis on medical devices nonetheless remains an elusive goal. Herein, we utilize a mineralized strategy coupled with ion exchange to generate lamellar-type magnesium calcium phosphate thin films with a three-step pathway: Construction of nanofiber porous structure on the substrate as ions reservoir, incorporation of magnesium substitutional transition sodium titanate layer, and mineralization of a lamellar calcium phosphate coating. Synthetic lamellar coatings exhibit excellent osteointegration effects in infectious scenarios. More importantly, the underlying transition layer can blow up the possible delayed infection like a landmine after the upper calcium phosphate coating is degraded under the physiological environment. This work highlights the pivotal role of the magnesium ions in mediating the growth of the total morphosynthesis of calcium phosphate coating and the underlying magnesium titanate layer in ensuring the possibility to eliminate delayed infections under time-dependent degradation.http://www.sciencedirect.com/science/article/pii/S0264127523006482Late infectionAntibacterial coatingBiomimetic mineralizationOrthopedic implants |
| spellingShingle | Yikai Wang Zhongru Gou Siyuan Ma Zhihui Jin Sen Chen Jia Ye Zhigang Nie Zhihui Wan Chongda Zhang Yuxiao Ye Xiaohua Yu Zhaoming Ye Yijun Ren Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy Materials & Design Late infection Antibacterial coating Biomimetic mineralization Orthopedic implants |
| title | Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy |
| title_full | Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy |
| title_fullStr | Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy |
| title_full_unstemmed | Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy |
| title_short | Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy |
| title_sort | remote eradication of delayed infection on orthopedic implants via magnesium based total morphosynthesis of biomimetic mineralization strategy |
| topic | Late infection Antibacterial coating Biomimetic mineralization Orthopedic implants |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523006482 |
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