Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women
Objectives: Micronutrients, especially calcium (Ca) and magnesium (Mg) are reported to reduce preeclampsia events via several factors such as endothelial cell control, optimal oxidative stress and a balanced angiogenic growth mediator. We evaluated the association of micronutrients with oxidative st...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-06-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121231175759 |
| _version_ | 1827932169618587648 |
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| author | Enoch Odame Anto Wina Ivy Ofori Boadu Otchere Addai-Mensah Yaw Amo Wiafe William KBA Owiredu Christian Obirikorang Max Efui Annani-Akollor Eric Adua Michael Appiah Stephen Opoku Emmanuel Acheampong Evans Adu Asamoah Eddie-Williams Owiredu Agartha Odame Anto Augustine Tawiah Frank Ankobea Ebenezer Afrifa Yamoah David Antony Coall |
| author_facet | Enoch Odame Anto Wina Ivy Ofori Boadu Otchere Addai-Mensah Yaw Amo Wiafe William KBA Owiredu Christian Obirikorang Max Efui Annani-Akollor Eric Adua Michael Appiah Stephen Opoku Emmanuel Acheampong Evans Adu Asamoah Eddie-Williams Owiredu Agartha Odame Anto Augustine Tawiah Frank Ankobea Ebenezer Afrifa Yamoah David Antony Coall |
| author_sort | Enoch Odame Anto |
| collection | DOAJ |
| description | Objectives: Micronutrients, especially calcium (Ca) and magnesium (Mg) are reported to reduce preeclampsia events via several factors such as endothelial cell control, optimal oxidative stress and a balanced angiogenic growth mediator. We evaluated the association of micronutrients with oxidative stress biomarkers, and angiogenic growth mediators in early-onset preeclampsia and late-onset preeclampsia. Methods: This case-control study recruited 197 preeclampsia (early-onset preeclampsia = 70 and late-onset preeclampsia = 127) as cases and 301 normotensive pregnant women as controls from the Komfo Anokye Teaching Hospital, Ghana. Samples were collected after 20 weeks of gestation for both cases and controls and estimated for Ca, Mg, soluble fms-like tyrosine kinase-1, placental growth factor, vascular endothelial growth factor-A, soluble endoglin, 8-hydroxydeoxyguanosine, 8-epiprostaglandinF2-alpha and total antioxidant capacity. Results: Early-onset preeclampsia women had significantly lower levels of Ca, Mg, placental growth factor, vascular endothelial growth factor-A and total antioxidant capacity but higher levels of soluble fms-like tyrosine kinase-1, soluble endoglin, 8-epiprostaglandinF2-alpha, 8-hydroxydeoxyguanosine, soluble fms-like tyrosine kinase-1/placental growth factor ratio, 8-epiprostaglandinF2-alpha /placental growth factor ratio, 8-hydroxydeoxyguanosine/placental growth factor ratio and soluble endoglin/placental growth factor ratio than late-onset preeclampsia and normotensive pregnant women ( p < 0.0001). Among the early-onset preeclampsia women, the first and second quartile for serum placental growth factor, first quartile for vascular endothelial growth factor-A and total antioxidant capacity and the fourth quartiles for serum sEng, serum sFlt-1, 8-epiPGF2α and 8-OHdG were independently associated with low Ca and Mg ( p < 0.05). Among late-onset preeclampsia women, the fourth quartile for soluble fms-like tyrosine kinase-1 was independently associated with low Ca and Mg ( p < 0.05). Conclusion: Magnesium and calcium are associated with an imbalance in angiogenic growth mediators and oxidative stress biomarkers among preeclampsia women, particularly early-onset preeclampsia. Serial and routine measurement of these micronutrients would allow the monitoring of poor placental angiogenesis while enabling an understanding of the triggers of increased oxidative stress and reduced antioxidant in preeclampsia. |
| first_indexed | 2024-03-13T07:04:47Z |
| format | Article |
| id | doaj.art-c332cb1f28a749ca9c222dc8a4708464 |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-03-13T07:04:47Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-c332cb1f28a749ca9c222dc8a47084642023-06-06T13:33:25ZengSAGE PublishingSAGE Open Medicine2050-31212023-06-011110.1177/20503121231175759Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian womenEnoch Odame Anto0Wina Ivy Ofori Boadu1Otchere Addai-Mensah2Yaw Amo Wiafe3William KBA Owiredu4Christian Obirikorang5Max Efui Annani-Akollor6Eric Adua7Michael Appiah8Stephen Opoku9Emmanuel Acheampong10Evans Adu Asamoah11Eddie-Williams Owiredu12Agartha Odame Anto13Augustine Tawiah14Frank Ankobea15Ebenezer Afrifa Yamoah16David Antony Coall17Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Perth, WA, AustraliaDepartment of Medical Diagnostic, Faculty of Allied Health Science, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Medical Diagnostic, Faculty of Allied Health Science, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Medical Diagnostic, Faculty of Allied Health Science, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaRural Clinical School, Medicine and Health, University of New South Wales, Wagga Wagga, NSW, AustraliaDepartment of Medical Laboratory Science, Accra Technical University, Accra, GhanaDepartment of Medical Diagnostic, Faculty of Allied Health Science, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaRural Clinical School, Medicine and Health, University of New South Wales, Wagga Wagga, NSW, AustraliaDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Obstetrics and Gynaecology, Ho Teaching Hospital, Volta Region, Ho, GhanaDepartment of Obstetrics and Gynaecology, Komfo Anokye Teaching Hospital, Kumasi, GhanaDepartment of Obstetrics and Gynaecology, Komfo Anokye Teaching Hospital, Kumasi, GhanaSchool of Sciences, Edith Cowan University, Perth, WA, AustraliaCentre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Perth, WA, AustraliaObjectives: Micronutrients, especially calcium (Ca) and magnesium (Mg) are reported to reduce preeclampsia events via several factors such as endothelial cell control, optimal oxidative stress and a balanced angiogenic growth mediator. We evaluated the association of micronutrients with oxidative stress biomarkers, and angiogenic growth mediators in early-onset preeclampsia and late-onset preeclampsia. Methods: This case-control study recruited 197 preeclampsia (early-onset preeclampsia = 70 and late-onset preeclampsia = 127) as cases and 301 normotensive pregnant women as controls from the Komfo Anokye Teaching Hospital, Ghana. Samples were collected after 20 weeks of gestation for both cases and controls and estimated for Ca, Mg, soluble fms-like tyrosine kinase-1, placental growth factor, vascular endothelial growth factor-A, soluble endoglin, 8-hydroxydeoxyguanosine, 8-epiprostaglandinF2-alpha and total antioxidant capacity. Results: Early-onset preeclampsia women had significantly lower levels of Ca, Mg, placental growth factor, vascular endothelial growth factor-A and total antioxidant capacity but higher levels of soluble fms-like tyrosine kinase-1, soluble endoglin, 8-epiprostaglandinF2-alpha, 8-hydroxydeoxyguanosine, soluble fms-like tyrosine kinase-1/placental growth factor ratio, 8-epiprostaglandinF2-alpha /placental growth factor ratio, 8-hydroxydeoxyguanosine/placental growth factor ratio and soluble endoglin/placental growth factor ratio than late-onset preeclampsia and normotensive pregnant women ( p < 0.0001). Among the early-onset preeclampsia women, the first and second quartile for serum placental growth factor, first quartile for vascular endothelial growth factor-A and total antioxidant capacity and the fourth quartiles for serum sEng, serum sFlt-1, 8-epiPGF2α and 8-OHdG were independently associated with low Ca and Mg ( p < 0.05). Among late-onset preeclampsia women, the fourth quartile for soluble fms-like tyrosine kinase-1 was independently associated with low Ca and Mg ( p < 0.05). Conclusion: Magnesium and calcium are associated with an imbalance in angiogenic growth mediators and oxidative stress biomarkers among preeclampsia women, particularly early-onset preeclampsia. Serial and routine measurement of these micronutrients would allow the monitoring of poor placental angiogenesis while enabling an understanding of the triggers of increased oxidative stress and reduced antioxidant in preeclampsia.https://doi.org/10.1177/20503121231175759 |
| spellingShingle | Enoch Odame Anto Wina Ivy Ofori Boadu Otchere Addai-Mensah Yaw Amo Wiafe William KBA Owiredu Christian Obirikorang Max Efui Annani-Akollor Eric Adua Michael Appiah Stephen Opoku Emmanuel Acheampong Evans Adu Asamoah Eddie-Williams Owiredu Agartha Odame Anto Augustine Tawiah Frank Ankobea Ebenezer Afrifa Yamoah David Antony Coall Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women SAGE Open Medicine |
| title | Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women |
| title_full | Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women |
| title_fullStr | Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women |
| title_full_unstemmed | Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women |
| title_short | Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women |
| title_sort | association between micronutrients oxidative stress biomarkers and angiogenic growth mediators in early and late onset preeclamptic ghanaian women |
| url | https://doi.org/10.1177/20503121231175759 |
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