Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

Summary: A major feature of amyotrophic lateral sclerosis (ALS) pathology is the accumulation of ubiquitin (Ub) into intracellular inclusions. This sequestration of Ub may reduce the availability of free Ub, disrupting Ub homeostasis and ultimately compromising cellular function and survival. We pre...

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Bibliographic Details
Main Authors:	Natalie E. Farrawell, Luke McAlary, Jeremy S. Lum, Christen G. Chisholm, Sadaf T. Warraich, Ian P. Blair, Kara L. Vine, Darren N. Saunders, Justin J. Yerbury
Format:	Article
Language:	English
Published:	Elsevier 2020-11-01
Series:	iScience
Subjects:	Molecular Biology Neuroscience Protein Folding
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004220308920

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