Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling Analysis
Chen Li,1 Hao Wu,2 Han Li,3 Quan Wang,1 Yang Li,1 Zhi-Dong Gao,1 Xiao-Dong Yang,1 Ying-Jiang Ye,1 Ke-Wei Jiang1 1Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People&rsqu...
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| Format: | Article |
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Dove Medical Press
2021-02-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/different-medical-features-and-strategies-of-large-rectal-gastrointest-peer-reviewed-article-CMAR |
| _version_ | 1819282652165832704 |
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| author | Li C Wu H Li H Wang Q Li Y Gao ZD Yang XD Ye YJ Jiang KW |
| author_facet | Li C Wu H Li H Wang Q Li Y Gao ZD Yang XD Ye YJ Jiang KW |
| author_sort | Li C |
| collection | DOAJ |
| description | Chen Li,1 Hao Wu,2 Han Li,3 Quan Wang,1 Yang Li,1 Zhi-Dong Gao,1 Xiao-Dong Yang,1 Ying-Jiang Ye,1 Ke-Wei Jiang1 1Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Gastroenterological Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People’s Republic of China; 3Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong Province, People’s Republic of ChinaCorrespondence: Ke-Wei JiangDepartment of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of ChinaTel +86 135 1107 8178Fax +86 (10) 8832 6600Email jiangkewei@pkuph.edu.cnPurpose: The rectum is a rare site for gastrointestinal stromal tumors (GISTs). Tumors in this critical anatomical site are prone to develop local recurrence, and this occurs at a high level even in low-risk tumors. Previous studies found that high-risk was the most common category in rectal gastrointestinal stromal tumors (RGISTs), and size was the most important factor affecting the long-term prognosis. We aimed to find out the most influential factor on clinical outcomes, and describe demographics, oncological differences, and surgical procedures in patients with poor prognosis.Patients and Methods: Data on consecutive patients with RGIST, who were diagnosed at Peking University People’s Hospital, Shandong Province Hospital, and The First Affiliated Hospital of Shandong First Medical University from 2010 to 2020, were retrospectively evaluated. Further, a literature search was conducted by retrieving data from PubMed, EMBASE, and the Cochrane Library databases from inception up to March 20, 2020.Results: In all, 50 patients were diagnosed with RGIST at three medical centers, and 86 published records were finally included in the literature review. Combined analysis of the whole individual patient data showed that 5.5 cm was deemed an appropriate cut-off value for L-RGIST, and that patients usually showed a male predominance (67.59%), younger age at onset (56.61 years), higher operative difficulty, and poorer prognosis.Conclusion: Separation of patients with large RGIST from general patients may contribute to the recognition of the oncological characteristics and clinical management of this rare type of tumor.Keywords: gastrointestinal stromal tumor, rectum, cut-off value, multi-center, operation |
| first_indexed | 2024-12-24T01:18:59Z |
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| id | doaj.art-c336ee828788485b830ba63bccfd7879 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-24T01:18:59Z |
| publishDate | 2021-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-c336ee828788485b830ba63bccfd78792022-12-21T17:22:43ZengDove Medical PressCancer Management and Research1179-13222021-02-01Volume 131591160062234Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling AnalysisLi CWu HLi HWang QLi YGao ZDYang XDYe YJJiang KWChen Li,1 Hao Wu,2 Han Li,3 Quan Wang,1 Yang Li,1 Zhi-Dong Gao,1 Xiao-Dong Yang,1 Ying-Jiang Ye,1 Ke-Wei Jiang1 1Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Gastroenterological Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People’s Republic of China; 3Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong Province, People’s Republic of ChinaCorrespondence: Ke-Wei JiangDepartment of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of ChinaTel +86 135 1107 8178Fax +86 (10) 8832 6600Email jiangkewei@pkuph.edu.cnPurpose: The rectum is a rare site for gastrointestinal stromal tumors (GISTs). Tumors in this critical anatomical site are prone to develop local recurrence, and this occurs at a high level even in low-risk tumors. Previous studies found that high-risk was the most common category in rectal gastrointestinal stromal tumors (RGISTs), and size was the most important factor affecting the long-term prognosis. We aimed to find out the most influential factor on clinical outcomes, and describe demographics, oncological differences, and surgical procedures in patients with poor prognosis.Patients and Methods: Data on consecutive patients with RGIST, who were diagnosed at Peking University People’s Hospital, Shandong Province Hospital, and The First Affiliated Hospital of Shandong First Medical University from 2010 to 2020, were retrospectively evaluated. Further, a literature search was conducted by retrieving data from PubMed, EMBASE, and the Cochrane Library databases from inception up to March 20, 2020.Results: In all, 50 patients were diagnosed with RGIST at three medical centers, and 86 published records were finally included in the literature review. Combined analysis of the whole individual patient data showed that 5.5 cm was deemed an appropriate cut-off value for L-RGIST, and that patients usually showed a male predominance (67.59%), younger age at onset (56.61 years), higher operative difficulty, and poorer prognosis.Conclusion: Separation of patients with large RGIST from general patients may contribute to the recognition of the oncological characteristics and clinical management of this rare type of tumor.Keywords: gastrointestinal stromal tumor, rectum, cut-off value, multi-center, operationhttps://www.dovepress.com/different-medical-features-and-strategies-of-large-rectal-gastrointest-peer-reviewed-article-CMARgastrointestinal stromal tumorrectumcut-off valuemulti-centeroperation |
| spellingShingle | Li C Wu H Li H Wang Q Li Y Gao ZD Yang XD Ye YJ Jiang KW Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling Analysis Cancer Management and Research gastrointestinal stromal tumor rectum cut-off value multi-center operation |
| title | Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling Analysis |
| title_full | Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling Analysis |
| title_fullStr | Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling Analysis |
| title_full_unstemmed | Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling Analysis |
| title_short | Different Medical Features and Strategies of Large Rectal Gastrointestinal Stromal Tumor: A Multi-Central Pooling Analysis |
| title_sort | different medical features and strategies of large rectal gastrointestinal stromal tumor a multi central pooling analysis |
| topic | gastrointestinal stromal tumor rectum cut-off value multi-center operation |
| url | https://www.dovepress.com/different-medical-features-and-strategies-of-large-rectal-gastrointest-peer-reviewed-article-CMAR |
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