In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma
Introduction: Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic ma...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869418304841 |
| _version_ | 1818664005482315776 |
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| author | Qing Ye Jing Li Xiaoyan Wang Xianzeng Zhang Jun Lin Yuting Huo Zhengzhen Sun Shusen Xie Zheng Huang |
| author_facet | Qing Ye Jing Li Xiaoyan Wang Xianzeng Zhang Jun Lin Yuting Huo Zhengzhen Sun Shusen Xie Zheng Huang |
| author_sort | Qing Ye |
| collection | DOAJ |
| description | Introduction: Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies. Objective: To study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma. Methods: The expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n = 42) and nasopharyngitis patients (n = 22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined. Results: The expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p < 0.05). Their expression in nasopharyngeal carcinoma with metastasis were significantly higher than that without metastasis (p < 0.05), which was correlated with TNM staging (p < 0.05). High Cripto-1 expression and high proliferation rate were seen in CNE1-LMP1 cells. Conclusions: The expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma is positively related. Their co-expression might contribute to the proliferation and metastasis of nasopharyngeal carcinoma. Resumo: Introdução: O carcinoma nasofaríngeo é um tumor maligno derivado do epitélio de localização anatômica recôndita e sintomas iniciais atípicos; quando diagnosticado, frequentemente invasão e metástases já ocorreram. Isso requer uma melhor compreensão do seu mecanismo de desenvolvimento, identificação dos marcadores diagnósticos e desenvolvimento de novas estratégias de tratamento. Objetivo: Estudar a relação de LMP1 e Cripto-1 no carcinoma nasofaríngeo. Método: A expressão de LMP1 e Cripto-1 em espécimes obtidos de pacientes com carcinoma de nasofaringe (n = 42) e pacientes com nasofaringite (n = 22) foi analisada. A expressão de LMP1 e Cripto-1 em células LMP1-negativas e LMP1-positivas (CNE1-LMP1) também foi analisada. Resultados: A expressão de LMP1 e Cripto-1 foi significantemente maior na presença de carcinoma nasofaríngeo do que na nasofaringite (p < 0,05). Sua expressão em carcinomas com metástase foi significantemente maior do que em casos sem metástase (p < 0,05), o que se correlacionou com o estadiamento TNM (p < 0,05). Uma alta expressão de Cripto-1 e alta taxa de proliferação foram observadas nas células CNE1-LMP1. Conclusões: A expressão de LMP1 e Cripto-1 é positivamente relacionada com carcinoma nasofaríngeo. Sua coexpressão pode ser atribuída à proliferação e metástase do tumor. |
| first_indexed | 2024-12-17T05:25:52Z |
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| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-12-17T05:25:52Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-c3383e49f69045e38733c2169ebd84202022-12-21T22:01:52ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942020-09-01865617625In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinomaQing Ye0Jing Li1Xiaoyan Wang2Xianzeng Zhang3Jun Lin4Yuting Huo5Zhengzhen Sun6Shusen Xie7Zheng Huang8Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, ChinaFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China; Corresponding author.Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, ChinaFujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, ChinaFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, ChinaFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, ChinaFujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, ChinaFujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, ChinaFujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, ChinaIntroduction: Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies. Objective: To study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma. Methods: The expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n = 42) and nasopharyngitis patients (n = 22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined. Results: The expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p < 0.05). Their expression in nasopharyngeal carcinoma with metastasis were significantly higher than that without metastasis (p < 0.05), which was correlated with TNM staging (p < 0.05). High Cripto-1 expression and high proliferation rate were seen in CNE1-LMP1 cells. Conclusions: The expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma is positively related. Their co-expression might contribute to the proliferation and metastasis of nasopharyngeal carcinoma. Resumo: Introdução: O carcinoma nasofaríngeo é um tumor maligno derivado do epitélio de localização anatômica recôndita e sintomas iniciais atípicos; quando diagnosticado, frequentemente invasão e metástases já ocorreram. Isso requer uma melhor compreensão do seu mecanismo de desenvolvimento, identificação dos marcadores diagnósticos e desenvolvimento de novas estratégias de tratamento. Objetivo: Estudar a relação de LMP1 e Cripto-1 no carcinoma nasofaríngeo. Método: A expressão de LMP1 e Cripto-1 em espécimes obtidos de pacientes com carcinoma de nasofaringe (n = 42) e pacientes com nasofaringite (n = 22) foi analisada. A expressão de LMP1 e Cripto-1 em células LMP1-negativas e LMP1-positivas (CNE1-LMP1) também foi analisada. Resultados: A expressão de LMP1 e Cripto-1 foi significantemente maior na presença de carcinoma nasofaríngeo do que na nasofaringite (p < 0,05). Sua expressão em carcinomas com metástase foi significantemente maior do que em casos sem metástase (p < 0,05), o que se correlacionou com o estadiamento TNM (p < 0,05). Uma alta expressão de Cripto-1 e alta taxa de proliferação foram observadas nas células CNE1-LMP1. Conclusões: A expressão de LMP1 e Cripto-1 é positivamente relacionada com carcinoma nasofaríngeo. Sua coexpressão pode ser atribuída à proliferação e metástase do tumor.http://www.sciencedirect.com/science/article/pii/S1808869418304841Carcinoma nasofaríngeoLMP1Cripto-1Metástase |
| spellingShingle | Qing Ye Jing Li Xiaoyan Wang Xianzeng Zhang Jun Lin Yuting Huo Zhengzhen Sun Shusen Xie Zheng Huang In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma Brazilian Journal of Otorhinolaryngology Carcinoma nasofaríngeo LMP1 Cripto-1 Metástase |
| title | In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma |
| title_full | In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma |
| title_fullStr | In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma |
| title_full_unstemmed | In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma |
| title_short | In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma |
| title_sort | in vivo and in vitro study of co expression of lmp1 and cripto 1 in nasopharyngeal carcinoma |
| topic | Carcinoma nasofaríngeo LMP1 Cripto-1 Metástase |
| url | http://www.sciencedirect.com/science/article/pii/S1808869418304841 |
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