Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons

Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons

This study investigated human-induced pluripotent stem cell (hiPSC) -derived neurons for their ability to secrete neurotransmitters in an activity-dependent manner, the fundamental property required for chemical neurotransmission. Cultured hiPSC neurons showed KCl stimulation of activity-dependent s...

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Bibliographic Details
Main Authors: Vivian Hook, Kristen J. Brennand, Yongsung Kim, Thomas Toneff, Lydiane Funkelstein, Kelly C. Lee, Michael Ziegler, Fred H. Gage
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114002458

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