A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells
A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 10<sup>8</sup> nanoparticles per mL. On the basis of...
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2021-11-01
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| author | Veronika V. Smirnova Denis N. Chausov Dmitriy A. Serov Valery A. Kozlov Petr I. Ivashkin Roman Y. Pishchalnikov Oleg V. Uvarov Maria V. Vedunova Anastasia A. Semenova Andrey B. Lisitsyn Alexander V. Simakin |
| author_facet | Veronika V. Smirnova Denis N. Chausov Dmitriy A. Serov Valery A. Kozlov Petr I. Ivashkin Roman Y. Pishchalnikov Oleg V. Uvarov Maria V. Vedunova Anastasia A. Semenova Andrey B. Lisitsyn Alexander V. Simakin |
| author_sort | Veronika V. Smirnova |
| collection | DOAJ |
| description | A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 10<sup>8</sup> nanoparticles per mL. On the basis of the obtained nanoparticles and the PLGA polymer, a nanocomposite material was manufactured. The manufacturing technology allows one to obtain a nanocomposite material without significant defects. Nanoparticles are not evenly distributed in the material and form domains in the composite. Reactive oxygen species (hydrogen peroxide and hydroxyl radical) are intensively generated on the surfaces of the nanocomposite. Additionally, on the surface of the composite material, an intensive formation of protein long-lived active forms is observed. The ELISA method was used to demonstrate the generation of 8-oxoguanine in DNA on the developed nanocomposite material. It was found that the multiplication of microorganisms on the developed nanocomposite material is significantly decreased. At the same time, the nanocomposite does not inhibit proliferation of mammalian cells. The developed nanocomposite material can be used as an affordable and non-toxic nanomaterial to create bacteriostatic coatings that are safe for humans. |
| first_indexed | 2024-03-10T05:20:03Z |
| format | Article |
| id | doaj.art-c33b7d20e02e43b7ab6644357d7ca734 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T05:20:03Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-c33b7d20e02e43b7ab6644357d7ca7342023-11-23T00:10:48ZengMDPI AGMaterials1996-19442021-11-011422691510.3390/ma14226915A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian CellsVeronika V. Smirnova0Denis N. Chausov1Dmitriy A. Serov2Valery A. Kozlov3Petr I. Ivashkin4Roman Y. Pishchalnikov5Oleg V. Uvarov6Maria V. Vedunova7Anastasia A. Semenova8Andrey B. Lisitsyn9Alexander V. Simakin10Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaV. M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, 109316 Moscow, RussiaV. M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, 109316 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, RussiaA method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 10<sup>8</sup> nanoparticles per mL. On the basis of the obtained nanoparticles and the PLGA polymer, a nanocomposite material was manufactured. The manufacturing technology allows one to obtain a nanocomposite material without significant defects. Nanoparticles are not evenly distributed in the material and form domains in the composite. Reactive oxygen species (hydrogen peroxide and hydroxyl radical) are intensively generated on the surfaces of the nanocomposite. Additionally, on the surface of the composite material, an intensive formation of protein long-lived active forms is observed. The ELISA method was used to demonstrate the generation of 8-oxoguanine in DNA on the developed nanocomposite material. It was found that the multiplication of microorganisms on the developed nanocomposite material is significantly decreased. At the same time, the nanocomposite does not inhibit proliferation of mammalian cells. The developed nanocomposite material can be used as an affordable and non-toxic nanomaterial to create bacteriostatic coatings that are safe for humans.https://www.mdpi.com/1996-1944/14/22/6915nanocomposite polymer materialPLGAsilver oxide nanoparticlesreactive oxygen speciesbacteriostatic properties |
| spellingShingle | Veronika V. Smirnova Denis N. Chausov Dmitriy A. Serov Valery A. Kozlov Petr I. Ivashkin Roman Y. Pishchalnikov Oleg V. Uvarov Maria V. Vedunova Anastasia A. Semenova Andrey B. Lisitsyn Alexander V. Simakin A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells Materials nanocomposite polymer material PLGA silver oxide nanoparticles reactive oxygen species bacteriostatic properties |
| title | A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells |
| title_full | A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells |
| title_fullStr | A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells |
| title_full_unstemmed | A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells |
| title_short | A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells |
| title_sort | novel biodegradable composite polymer material based on plga and silver oxide nanoparticles with unique physicochemical properties and biocompatibility with mammalian cells |
| topic | nanocomposite polymer material PLGA silver oxide nanoparticles reactive oxygen species bacteriostatic properties |
| url | https://www.mdpi.com/1996-1944/14/22/6915 |
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