Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities
Background: Asthma is a common disease in the world and vitamin D (Vit-D) has been associated with the presence and severity of this disease. Objective: To establish the association between levels of Vit-D and IgE response in schoolchildren with asthma living in four cities in Colombia. Methods: C...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2016-08-01
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| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/183 |
| _version_ | 1797766469200642048 |
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| author | Eduardo Egea Gloria Garavito Luis Carlos Fang-Mercado Dary Luz Mendoza José Miguel Escamilla Elsie De los Rios Rodolfo Dennis Mario Sanchez-Borges |
| author_facet | Eduardo Egea Gloria Garavito Luis Carlos Fang-Mercado Dary Luz Mendoza José Miguel Escamilla Elsie De los Rios Rodolfo Dennis Mario Sanchez-Borges |
| author_sort | Eduardo Egea |
| collection | DOAJ |
| description | Background: Asthma is a common disease in the world and vitamin D (Vit-D) has been associated with the presence and severity of this disease.
Objective: To establish the association between levels of Vit-D and IgE response in schoolchildren with asthma living in four cities in Colombia.
Methods: Case-control study in 1340 schoolchildren (687 asthmatic and 653 controls) from communities in extreme poverty in Barranquilla, Cartagena, Santa Marta, and Montería. Serum concentrations of Vit-D, total IgE, and anti-Dermatophagoides farinae, Periplaneta americana, and Ascaris lumbricoides (AL) specific IgE were measured.
Results: Controls reported higher concentrations of Vit-D [61.9 ± 28.4 ng/mL] than cases [53 ± 23.3 ng / mL] (p < 0.05). Total IgE was higher in cases (p < 0.05). Only anti-AL IgE showed a clear difference: in controls, optical density was 0.27 ± 0.25; in cases, 0.22 ± 0.24 (p < 0.05). Vit-D showed differences between cases and controls in each population.
Conclusions: An association could not be demonstrated between Vit-D deficiency and asthma, as total IgE was elevated in patients and controls. The results suggest that Vit-D influences the specif IgE response in poor asthmatic children in areas endemic for helminthiasis. |
| first_indexed | 2024-03-12T20:24:46Z |
| format | Article |
| id | doaj.art-c33c87d20be5412a91101ea4b882969b |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T20:24:46Z |
| publishDate | 2016-08-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-c33c87d20be5412a91101ea4b882969b2023-08-02T00:35:21ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902016-08-0163325226910.29262/ram.v63i3.183132Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communitiesEduardo Egea0Gloria Garavito1Luis Carlos Fang-Mercado2Dary Luz Mendoza3José Miguel Escamilla4Elsie De los Rios5Rodolfo DennisMario Sanchez-Borges6Universidad del Norte, División Ciencias de la Salud, Grupo de Investigación en Inmunología y Biología Molecular, BarranquillaUniversidad del Norte, División Ciencias de la Salud, Grupo de Investigación en Inmunología y Biología Molecular, BarranquillaUniversidad de Cartagena, Facultad de Odontología, Grupo de Investigaciones GITOUC, Cartagena de IndiasUniversidad del Atlántico, Facultad de Ciencias Básicas, Laboratorio de Bioquímica de Macromoléculas, BarranquillaUniversidad de Cartagena, Facultad de Medicina, CartagenaClínica Saima, Unidad de Alergología, MonteríaCentro Medico Docente La Trinidad, Departamento de Alergia e Inmunología Clínica, CaracasBackground: Asthma is a common disease in the world and vitamin D (Vit-D) has been associated with the presence and severity of this disease. Objective: To establish the association between levels of Vit-D and IgE response in schoolchildren with asthma living in four cities in Colombia. Methods: Case-control study in 1340 schoolchildren (687 asthmatic and 653 controls) from communities in extreme poverty in Barranquilla, Cartagena, Santa Marta, and Montería. Serum concentrations of Vit-D, total IgE, and anti-Dermatophagoides farinae, Periplaneta americana, and Ascaris lumbricoides (AL) specific IgE were measured. Results: Controls reported higher concentrations of Vit-D [61.9 ± 28.4 ng/mL] than cases [53 ± 23.3 ng / mL] (p < 0.05). Total IgE was higher in cases (p < 0.05). Only anti-AL IgE showed a clear difference: in controls, optical density was 0.27 ± 0.25; in cases, 0.22 ± 0.24 (p < 0.05). Vit-D showed differences between cases and controls in each population. Conclusions: An association could not be demonstrated between Vit-D deficiency and asthma, as total IgE was elevated in patients and controls. The results suggest that Vit-D influences the specif IgE response in poor asthmatic children in areas endemic for helminthiasis.http://revistaalergia.mx/ojs/index.php/ram/article/view/183Vitamina DIgE alérgenosAsma pediátricaNiñoAscaris lumbricoides |
| spellingShingle | Eduardo Egea Gloria Garavito Luis Carlos Fang-Mercado Dary Luz Mendoza José Miguel Escamilla Elsie De los Rios Rodolfo Dennis Mario Sanchez-Borges Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities Revista Alergia México Vitamina D IgE alérgenos Asma pediátrica Niño Ascaris lumbricoides |
| title | Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities |
| title_full | Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities |
| title_fullStr | Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities |
| title_full_unstemmed | Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities |
| title_short | Influence of serum levels of vitamin D on IgE response in schoolchildren with asthma in poor communities |
| title_sort | influence of serum levels of vitamin d on ige response in schoolchildren with asthma in poor communities |
| topic | Vitamina D IgE alérgenos Asma pediátrica Niño Ascaris lumbricoides |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/183 |
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