Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients
Tuberculosis pericarditis as a potentially fatal complication of tuberculosis requires effective diagnosis and treatment. We evaluated the efficacy of interferon-gamma (IFN-gamma) and adenosine deaminase (ADA) for diagnosing tuberculosis pericarditis in a cohort of Iranian patients presenting with p...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2013-07-01
|
| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4413 |
| _version_ | 1818540682529210368 |
|---|---|
| author | Hamid Emadi Koochak Setareh Davoudi Abbas Salehi Omran Reyhaneh Mohsenipour Keveh Hajifathalian Behtash Saeidi Ali Akbar Amirzargar Maryam Sotoudeh Soroush Seifirad |
| author_facet | Hamid Emadi Koochak Setareh Davoudi Abbas Salehi Omran Reyhaneh Mohsenipour Keveh Hajifathalian Behtash Saeidi Ali Akbar Amirzargar Maryam Sotoudeh Soroush Seifirad |
| author_sort | Hamid Emadi Koochak |
| collection | DOAJ |
| description | Tuberculosis pericarditis as a potentially fatal complication of tuberculosis requires effective diagnosis and treatment. We evaluated the efficacy of interferon-gamma (IFN-gamma) and adenosine deaminase (ADA) for diagnosing tuberculosis pericarditis in a cohort of Iranian patients presenting with pericarditis. We enrolled 38 patients with presentation of pericarditis. All patients underwent diagnostic and therapeutic pericardiostomy with drainage and biopsy. Adenosine deaminase and interferon-gamma levels were determined in pericardial fluid samples of all patients. Pericardial tissue samples were submitted for histopathologic and microbiologic studies. Polymerase chain reaction (PCR) was performed on all pericardial fluid samples to detect Mycobacterium tuberculosis. From 38 patients with pericarditis, 7 cases were diagnosed as having tuberculosis pericarditis (18.4%). Mean concentration of interferon-gamma in tuberculosis group was significantly higher compared to non-tuberculosis group (69257 pg/l [range: 26600-148000] vs. 329 pg/l [range: 0-2200], P<0.000). Receiver operating characteristic (ROC) curve showed a value of 14400 pg/l as the cutoff point with a sensitivity of 100% and specificity of 100% for diagnosing tuberculosis pericardial effusion. Adenosine deaminase was not found to be significantly higher in tuberculosis group in comparison with non-tuberculosis causes of pericardial effusion (35.7 [range: 9-69] vs. 36.03 [range: 8-420], P=0.28). In this study interferon-gamma showed to be a valuable diagnostic test for detection of tuberculosis pericarditis among a cohort of Iranian patients. We suggest using interferon-gamma to diagnose tuberculosis pericarditis to make diagnose in case of suspicion. While in this study, adenosine deaminase measurement did not prove to have the characteristics of an accurate diagnostic test for tuberculosis pericarditis. |
| first_indexed | 2024-12-11T21:58:35Z |
| format | Article |
| id | doaj.art-c33f5573b5d54e94b42a89dd3974d579 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-11T21:58:35Z |
| publishDate | 2013-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-c33f5573b5d54e94b42a89dd3974d5792022-12-22T00:49:12ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942013-07-015174366Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian PatientsHamid Emadi Koochak0Setareh Davoudi1Abbas Salehi Omran2Reyhaneh Mohsenipour3Keveh Hajifathalian4Behtash Saeidi5Ali Akbar Amirzargar6Maryam Sotoudeh7Soroush Seifirad8Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran.Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran.Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Molecular Immunology Research Center, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran.Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Pediatric Cardiology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Tuberculosis pericarditis as a potentially fatal complication of tuberculosis requires effective diagnosis and treatment. We evaluated the efficacy of interferon-gamma (IFN-gamma) and adenosine deaminase (ADA) for diagnosing tuberculosis pericarditis in a cohort of Iranian patients presenting with pericarditis. We enrolled 38 patients with presentation of pericarditis. All patients underwent diagnostic and therapeutic pericardiostomy with drainage and biopsy. Adenosine deaminase and interferon-gamma levels were determined in pericardial fluid samples of all patients. Pericardial tissue samples were submitted for histopathologic and microbiologic studies. Polymerase chain reaction (PCR) was performed on all pericardial fluid samples to detect Mycobacterium tuberculosis. From 38 patients with pericarditis, 7 cases were diagnosed as having tuberculosis pericarditis (18.4%). Mean concentration of interferon-gamma in tuberculosis group was significantly higher compared to non-tuberculosis group (69257 pg/l [range: 26600-148000] vs. 329 pg/l [range: 0-2200], P<0.000). Receiver operating characteristic (ROC) curve showed a value of 14400 pg/l as the cutoff point with a sensitivity of 100% and specificity of 100% for diagnosing tuberculosis pericardial effusion. Adenosine deaminase was not found to be significantly higher in tuberculosis group in comparison with non-tuberculosis causes of pericardial effusion (35.7 [range: 9-69] vs. 36.03 [range: 8-420], P=0.28). In this study interferon-gamma showed to be a valuable diagnostic test for detection of tuberculosis pericarditis among a cohort of Iranian patients. We suggest using interferon-gamma to diagnose tuberculosis pericarditis to make diagnose in case of suspicion. While in this study, adenosine deaminase measurement did not prove to have the characteristics of an accurate diagnostic test for tuberculosis pericarditis.https://acta.tums.ac.ir/index.php/acta/article/view/4413Adenosine deaminaseInterferon-gammaPericarditisTuberculosis |
| spellingShingle | Hamid Emadi Koochak Setareh Davoudi Abbas Salehi Omran Reyhaneh Mohsenipour Keveh Hajifathalian Behtash Saeidi Ali Akbar Amirzargar Maryam Sotoudeh Soroush Seifirad Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients Acta Medica Iranica Adenosine deaminase Interferon-gamma Pericarditis Tuberculosis |
| title | Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients |
| title_full | Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients |
| title_fullStr | Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients |
| title_full_unstemmed | Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients |
| title_short | Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients |
| title_sort | diagnostic value of interferon gamma assay in tuberculosis pericardial effusions study on a cohort of iranian patients |
| topic | Adenosine deaminase Interferon-gamma Pericarditis Tuberculosis |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4413 |
| work_keys_str_mv | AT hamidemadikoochak diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT setarehdavoudi diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT abbassalehiomran diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT reyhanehmohsenipour diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT kevehhajifathalian diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT behtashsaeidi diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT aliakbaramirzargar diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT maryamsotoudeh diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients AT soroushseifirad diagnosticvalueofinterferongammaassayintuberculosispericardialeffusionsstudyonacohortofiranianpatients |