Valproate-associated Movement Disorder: A Literature Review
Valproate (VPA) was first synthesized in 1882, but it was only in the early 1960s that its anticonvulsant properties were discovered. The aim of this literature review is to evaluate the clinical epidemiological profile, pathological mechanisms, and management of VPA-associated movement disorder (MD...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2021-10-01
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| Series: | Prague Medical Report |
| Online Access: | https://pmr.lf1.cuni.cz/122/3/0140/ |
| _version_ | 1818930486127362048 |
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| author | Jamir Pitton Rissardo Ana Letícia Fornari Caprara Ícaro Durante |
| author_facet | Jamir Pitton Rissardo Ana Letícia Fornari Caprara Ícaro Durante |
| author_sort | Jamir Pitton Rissardo |
| collection | DOAJ |
| description | Valproate (VPA) was first synthesized in 1882, but it was only in the early 1960s that its anticonvulsant properties were discovered. The aim of this literature review is to evaluate the clinical epidemiological profile, pathological mechanisms, and management of VPA-associated movement disorder (MD). Relevant reports in six databases were identified and assessed by two reviewers without language restriction. A total of 138 reports containing 362 cases of subjects who developed a MD secondary to VPA were reported. The MD identified were parkinsonism (PKN) (252), myoclonus (MCL) (54), dystonia (DTN) (17), dyskinesia (DKN) (16), stutters (4), tics (3), akathisia (AKT) (1). In the not clearly defined group, 15 extrapyramidal symptoms, 3 AKT, 2 DTN, 1 rigidity, 1 unstable gait were assessed. The mean and median age was 55.8 (SD: 16.58) and 61 years (range: 4–87 years). The most common VPA-indication was epilepsy, and 51.36% were males. The mean and median time from the VPA start to the MD onset was 32.75 (SD: 30.05) and 21.15 months (range: 1 day – 20 years). The mean and median time from the VPA withdrawal until the MD recovery was 2.89 (SD: 2.79) and 3 months (1 day – 12 months). The most common management was drug withdrawal. A complete recovery was obtained in 80.61%. VPA-associated MD was extensively reported in the literature. PKN was the most well-described. Future studies need to clearly report the clinical history of the patient, considering the full investigation of other adverse events during their entire life. |
| first_indexed | 2024-12-20T04:01:27Z |
| format | Article |
| id | doaj.art-c3414399203445ec969d0272b945ec67 |
| institution | Directory Open Access Journal |
| issn | 1214-6994 2336-2936 |
| language | English |
| last_indexed | 2024-12-20T04:01:27Z |
| publishDate | 2021-10-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Prague Medical Report |
| spelling | doaj.art-c3414399203445ec969d0272b945ec672022-12-21T19:54:09ZengKarolinum PressPrague Medical Report1214-69942336-29362021-10-01122314018010.14712/23362936.2021.14Valproate-associated Movement Disorder: A Literature ReviewJamir Pitton Rissardohttps://orcid.org/0000-0001-6179-2177Ana Letícia Fornari Caprarahttps://orcid.org/0000-0002-8024-2354Ícaro DuranteValproate (VPA) was first synthesized in 1882, but it was only in the early 1960s that its anticonvulsant properties were discovered. The aim of this literature review is to evaluate the clinical epidemiological profile, pathological mechanisms, and management of VPA-associated movement disorder (MD). Relevant reports in six databases were identified and assessed by two reviewers without language restriction. A total of 138 reports containing 362 cases of subjects who developed a MD secondary to VPA were reported. The MD identified were parkinsonism (PKN) (252), myoclonus (MCL) (54), dystonia (DTN) (17), dyskinesia (DKN) (16), stutters (4), tics (3), akathisia (AKT) (1). In the not clearly defined group, 15 extrapyramidal symptoms, 3 AKT, 2 DTN, 1 rigidity, 1 unstable gait were assessed. The mean and median age was 55.8 (SD: 16.58) and 61 years (range: 4–87 years). The most common VPA-indication was epilepsy, and 51.36% were males. The mean and median time from the VPA start to the MD onset was 32.75 (SD: 30.05) and 21.15 months (range: 1 day – 20 years). The mean and median time from the VPA withdrawal until the MD recovery was 2.89 (SD: 2.79) and 3 months (1 day – 12 months). The most common management was drug withdrawal. A complete recovery was obtained in 80.61%. VPA-associated MD was extensively reported in the literature. PKN was the most well-described. Future studies need to clearly report the clinical history of the patient, considering the full investigation of other adverse events during their entire life.https://pmr.lf1.cuni.cz/122/3/0140/ |
| spellingShingle | Jamir Pitton Rissardo Ana Letícia Fornari Caprara Ícaro Durante Valproate-associated Movement Disorder: A Literature Review Prague Medical Report |
| title | Valproate-associated Movement Disorder: A Literature Review |
| title_full | Valproate-associated Movement Disorder: A Literature Review |
| title_fullStr | Valproate-associated Movement Disorder: A Literature Review |
| title_full_unstemmed | Valproate-associated Movement Disorder: A Literature Review |
| title_short | Valproate-associated Movement Disorder: A Literature Review |
| title_sort | valproate associated movement disorder a literature review |
| url | https://pmr.lf1.cuni.cz/122/3/0140/ |
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