Repeated Cycles of Chronic Intermittent Ethanol Exposure Increases Basal Glutamate in the Nucleus Accumbens of Mice without affecting glutamate transport

Repeated Cycles of Chronic Intermittent Ethanol Exposure Increases Basal Glutamate in the Nucleus Accumbens of Mice without affecting glutamate transport

Repeated cycles of chronic intermittent ethanol (CIE) exposure increase voluntary consumption of ethanol in mice. Previous work has shown that extracellular glutamate in the nucleus accumbens (NAc) is significantly elevated in ethanol dependent mice and that pharmacologically manipulating glutamate...

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Bibliographic Details
Main Authors: William C. Griffin, Vorani S. Ramachandra, Lori A Knackstedt, Howard C Becker
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Pharmacology
Subjects:
Microdialysis
Mouse
alcohol
uptake
transport
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00027/full

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