Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case Report
<i>Mycobacterium kansasii</i> infections predominantly manifest in immunocompromised people and are primarily responsible for lung disease and systemic disseminated infection. Osteopathy is a rare consequence of <i>M. kansasii</i> infection. Here, we present imaging data from...
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/11/1970 |
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| author | Lu Dai Yanyan Wu Xi Zhou Sen Liu Junping Fan Huaiya Xie Luo Wang Xinlun Tian Wenbing Xu |
| author_facet | Lu Dai Yanyan Wu Xi Zhou Sen Liu Junping Fan Huaiya Xie Luo Wang Xinlun Tian Wenbing Xu |
| author_sort | Lu Dai |
| collection | DOAJ |
| description | <i>Mycobacterium kansasii</i> infections predominantly manifest in immunocompromised people and are primarily responsible for lung disease and systemic disseminated infection. Osteopathy is a rare consequence of <i>M. kansasii</i> infection. Here, we present imaging data from a 44-year-old immunocompetent Chinese woman diagnosed with multiple bone destruction, particularly of the spine, secondary to <i>M. kansasii</i> pulmonary disease, which is easily misdiagnosed. The patient underwent an emergency operation after experiencing unexpected incomplete paraplegia during hospitalization, indicating an aggravation of bone destruction. Preoperative sputum testing and next-generation sequencing of DNA and RNA of intraoperative samples confirmed the diagnosis of <i>M. kansasii</i> infection. Treatment with anti-tuberculosis therapy and the subsequent patient response supported our diagnosis. Given the rarity of osteopathy secondary to <i>M. kansasii</i> infection in immunocompetent individuals, our case offers some insight into this diagnosis. |
| first_indexed | 2024-03-11T03:09:55Z |
| format | Article |
| id | doaj.art-c34219730ea246f99df1ccb5e3e0110a |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T03:09:55Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-c34219730ea246f99df1ccb5e3e0110a2023-11-18T07:43:32ZengMDPI AGDiagnostics2075-44182023-06-011311197010.3390/diagnostics13111970Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case ReportLu Dai0Yanyan Wu1Xi Zhou2Sen Liu3Junping Fan4Huaiya Xie5Luo Wang6Xinlun Tian7Wenbing Xu8Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, ChinaDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, ChinaDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China<i>Mycobacterium kansasii</i> infections predominantly manifest in immunocompromised people and are primarily responsible for lung disease and systemic disseminated infection. Osteopathy is a rare consequence of <i>M. kansasii</i> infection. Here, we present imaging data from a 44-year-old immunocompetent Chinese woman diagnosed with multiple bone destruction, particularly of the spine, secondary to <i>M. kansasii</i> pulmonary disease, which is easily misdiagnosed. The patient underwent an emergency operation after experiencing unexpected incomplete paraplegia during hospitalization, indicating an aggravation of bone destruction. Preoperative sputum testing and next-generation sequencing of DNA and RNA of intraoperative samples confirmed the diagnosis of <i>M. kansasii</i> infection. Treatment with anti-tuberculosis therapy and the subsequent patient response supported our diagnosis. Given the rarity of osteopathy secondary to <i>M. kansasii</i> infection in immunocompetent individuals, our case offers some insight into this diagnosis.https://www.mdpi.com/2075-4418/13/11/1970<i>Mycobacterium kansasii</i>bone destructionimmunocompetent |
| spellingShingle | Lu Dai Yanyan Wu Xi Zhou Sen Liu Junping Fan Huaiya Xie Luo Wang Xinlun Tian Wenbing Xu Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case Report Diagnostics <i>Mycobacterium kansasii</i> bone destruction immunocompetent |
| title | Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case Report |
| title_full | Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case Report |
| title_fullStr | Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case Report |
| title_full_unstemmed | Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case Report |
| title_short | Multiple Bone Destruction Secondary to <i>Mycobacterium kansasii</i> Pulmonary Disease: A Case Report |
| title_sort | multiple bone destruction secondary to i mycobacterium kansasii i pulmonary disease a case report |
| topic | <i>Mycobacterium kansasii</i> bone destruction immunocompetent |
| url | https://www.mdpi.com/2075-4418/13/11/1970 |
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