Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity

Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity

<i>N</i>-methyl-D-aspartate receptors (NMDARs) are important postsynaptic receptors that contribute to normal synaptic function and cell survival; however, when overactivated, as in Huntington’s disease (HD), NMDARs cause excitotoxicity. HD-affected striatal neurons show altered NMDAR cu...

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Bibliographic Details
Main Authors: Lígia Fão, Patrícia Coelho, Ricardo J. Rodrigues, A. Cristina Rego
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
fyn kinase
mutant huntingtin
NMDA receptors
Huntington’s disease
CREB
post-synaptic density
Online Access:https://www.mdpi.com/2073-4409/11/19/3063

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