Imipramine Influences Body Distribution of Supplemental Zinc Which May Enhance Antidepressant Action

Imipramine Influences Body Distribution of Supplemental Zinc Which May Enhance Antidepressant Action

Zinc (Zn) was found to enhance the antidepressant efficacy of imipramine (IMI) in human depression and animal tests/models of depression. However, the underlying mechanism for this effect remains unknown. We measured the effect of intragastric (<i>p.o.</i>) combined administration of IMI...

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Bibliographic Details
Main Authors: Anna Rafało-Ulińska, Ewa Poleszak, Aleksandra Szopa, Anna Serefko, Magdalena Rogowska, Ireneusz Sowa, Magdalena Wójciak, Bożena Muszyńska, Agata Krakowska, Joanna Gdula-Argasińska, Katarzyna Kała, Barbara Jasiewicz, Włodzimierz Opoka, Bernadeta Szewczyk, Gabriel Nowak
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Nutrients
Subjects:
imipramine
zinc
brain
blood
gastrointestinal tract
zinc transporters
Online Access:https://www.mdpi.com/2072-6643/12/9/2529

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