Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease
Breast cancer (BC) is the most frequent malignant neoplasia and leading cause of cancer mortality for women. A timely diagnosis of BC is crucial to ensure the best chances of survival. Among the various screening tools for BC, antibodies directed towards self-antigens or tumor-associated antigens (a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/10/634 |
| _version_ | 1797574231213473792 |
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| author | Jesús Pérez-Hernández Rosalba León-Díaz Alejandro Zentella Edmundo Lamoyi Marcela Esquivel-Velázquez Antonia Barranca-Enríquez Tania Romo-González |
| author_facet | Jesús Pérez-Hernández Rosalba León-Díaz Alejandro Zentella Edmundo Lamoyi Marcela Esquivel-Velázquez Antonia Barranca-Enríquez Tania Romo-González |
| author_sort | Jesús Pérez-Hernández |
| collection | DOAJ |
| description | Breast cancer (BC) is the most frequent malignant neoplasia and leading cause of cancer mortality for women. A timely diagnosis of BC is crucial to ensure the best chances of survival. Among the various screening tools for BC, antibodies directed towards self-antigens or tumor-associated antigens (autoantibodies) have emerged as an alternative to image-based screening modalities. However, little attention has been paid to the global diversity of autoantibodies. This work aimed to analyze the diversity of autoantibodies reactive to antigens expressed by the BC cell line T47D in the sera of Mexican women with BC, benign breast pathology (BBP), or without breast pathology (WBP). We found that the diversity of antibodies in the sera was higher in the BC and BBP groups than in the WBP group. Likewise, the diversity changed with the progression of BC. Our results show and measure the complexity of the antibody response in breast health and disease. |
| first_indexed | 2024-03-10T21:20:02Z |
| format | Article |
| id | doaj.art-c3458c55f81c42d48abf309eb0b1db96 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T21:20:02Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-c3458c55f81c42d48abf309eb0b1db962023-11-19T16:10:40ZengMDPI AGCurrent Oncology1198-00521718-77292023-09-0130108793880410.3390/curroncol30100634Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the DiseaseJesús Pérez-Hernández0Rosalba León-Díaz1Alejandro Zentella2Edmundo Lamoyi3Marcela Esquivel-Velázquez4Antonia Barranca-Enríquez5Tania Romo-González6Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City 06720, ZP, MexicoÁrea de Biología y Salud Integral, Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa 91190, ZP, MexicoDepartamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, ZP, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 04510, ZP, MexicoLaboratorio de Proteómica, Dirección de Investigación, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City 06720, ZP, MexicoCentro de Estudios y Servicios en Salud, Universidad Veracruzana, Veracruz 91700, ZP, MexicoÁrea de Biología y Salud Integral, Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa 91190, ZP, MexicoBreast cancer (BC) is the most frequent malignant neoplasia and leading cause of cancer mortality for women. A timely diagnosis of BC is crucial to ensure the best chances of survival. Among the various screening tools for BC, antibodies directed towards self-antigens or tumor-associated antigens (autoantibodies) have emerged as an alternative to image-based screening modalities. However, little attention has been paid to the global diversity of autoantibodies. This work aimed to analyze the diversity of autoantibodies reactive to antigens expressed by the BC cell line T47D in the sera of Mexican women with BC, benign breast pathology (BBP), or without breast pathology (WBP). We found that the diversity of antibodies in the sera was higher in the BC and BBP groups than in the WBP group. Likewise, the diversity changed with the progression of BC. Our results show and measure the complexity of the antibody response in breast health and disease.https://www.mdpi.com/1718-7729/30/10/634breast cancer progressionserological datadiversity analysisMexican womenautoantibodies |
| spellingShingle | Jesús Pérez-Hernández Rosalba León-Díaz Alejandro Zentella Edmundo Lamoyi Marcela Esquivel-Velázquez Antonia Barranca-Enríquez Tania Romo-González Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease Current Oncology breast cancer progression serological data diversity analysis Mexican women autoantibodies |
| title | Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease |
| title_full | Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease |
| title_fullStr | Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease |
| title_full_unstemmed | Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease |
| title_short | Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease |
| title_sort | autoantibody diversity is augmented in women with breast cancer and is related to the stage of the disease |
| topic | breast cancer progression serological data diversity analysis Mexican women autoantibodies |
| url | https://www.mdpi.com/1718-7729/30/10/634 |
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