Glioactive ATP controls BDNF recycling in cortical astrocytes
We have recently reported that long-term memory retention requires synaptic glia for proBDNF uptake and recycling. Through the recycling course, glial cells release endocytic BDNF, a mechanism that is activated in response to glutamate via AMPA and mGluRI/II receptors. Cortical astrocytes express re...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Communicative & Integrative Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19420889.2016.1277296 |
| _version_ | 1818932916953022464 |
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| author | Beatrice Vignoli Marco Canossa |
| author_facet | Beatrice Vignoli Marco Canossa |
| author_sort | Beatrice Vignoli |
| collection | DOAJ |
| description | We have recently reported that long-term memory retention requires synaptic glia for proBDNF uptake and recycling. Through the recycling course, glial cells release endocytic BDNF, a mechanism that is activated in response to glutamate via AMPA and mGluRI/II receptors. Cortical astrocytes express receptors for many different transmitters suggesting for a complex signaling controlling endocytic BDNF secretion. Here, we demonstrated that the extracellular nucleotide ATP, activating P2X and P2Y receptors, regulates endocytic BDNF secretion in cultured astrocytes. Our data indicate that distinct glioactive molecules can participate in BDNF glial recycling and suggest that cortical astrocytes contributing to neuronal plasticity can be influenced by neurotransmitters in tune with synaptic needs. |
| first_indexed | 2024-12-20T04:40:06Z |
| format | Article |
| id | doaj.art-c34611f39d1347c0a10f821f2d9eb602 |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-12-20T04:40:06Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-c34611f39d1347c0a10f821f2d9eb6022022-12-21T19:53:09ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892017-01-0110110.1080/19420889.2016.12772961277296Glioactive ATP controls BDNF recycling in cortical astrocytesBeatrice Vignoli0Marco Canossa1Centre for Integrative Biology (CIBIO), University of TrentoCentre for Integrative Biology (CIBIO), University of TrentoWe have recently reported that long-term memory retention requires synaptic glia for proBDNF uptake and recycling. Through the recycling course, glial cells release endocytic BDNF, a mechanism that is activated in response to glutamate via AMPA and mGluRI/II receptors. Cortical astrocytes express receptors for many different transmitters suggesting for a complex signaling controlling endocytic BDNF secretion. Here, we demonstrated that the extracellular nucleotide ATP, activating P2X and P2Y receptors, regulates endocytic BDNF secretion in cultured astrocytes. Our data indicate that distinct glioactive molecules can participate in BDNF glial recycling and suggest that cortical astrocytes contributing to neuronal plasticity can be influenced by neurotransmitters in tune with synaptic needs.http://dx.doi.org/10.1080/19420889.2016.1277296calciumglial networkgliotransmissionneurotrophinssynaptic plasticity |
| spellingShingle | Beatrice Vignoli Marco Canossa Glioactive ATP controls BDNF recycling in cortical astrocytes Communicative & Integrative Biology calcium glial network gliotransmission neurotrophins synaptic plasticity |
| title | Glioactive ATP controls BDNF recycling in cortical astrocytes |
| title_full | Glioactive ATP controls BDNF recycling in cortical astrocytes |
| title_fullStr | Glioactive ATP controls BDNF recycling in cortical astrocytes |
| title_full_unstemmed | Glioactive ATP controls BDNF recycling in cortical astrocytes |
| title_short | Glioactive ATP controls BDNF recycling in cortical astrocytes |
| title_sort | glioactive atp controls bdnf recycling in cortical astrocytes |
| topic | calcium glial network gliotransmission neurotrophins synaptic plasticity |
| url | http://dx.doi.org/10.1080/19420889.2016.1277296 |
| work_keys_str_mv | AT beatricevignoli glioactiveatpcontrolsbdnfrecyclingincorticalastrocytes AT marcocanossa glioactiveatpcontrolsbdnfrecyclingincorticalastrocytes |