Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small Animals
Photoacoustic imaging is a promising medical imaging technique that provides excellent function imaging of an underlying biological tissue or organ. However, it is limited in providing structural information compared to other imaging modalities, such as ultrasound imaging. Thus, to offer complete mo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/8/1/13 |
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| author | Eun-Yeong Park Sinyoung Park Haeni Lee Munsik Kang Chulhong Kim Jeesu Kim |
| author_facet | Eun-Yeong Park Sinyoung Park Haeni Lee Munsik Kang Chulhong Kim Jeesu Kim |
| author_sort | Eun-Yeong Park |
| collection | DOAJ |
| description | Photoacoustic imaging is a promising medical imaging technique that provides excellent function imaging of an underlying biological tissue or organ. However, it is limited in providing structural information compared to other imaging modalities, such as ultrasound imaging. Thus, to offer complete morphological details of biological tissues, photoacoustic imaging is typically integrated with ultrasound imaging. This dual-modal imaging technique is already implemented on commercial clinical ultrasound imaging platforms. However, commercial platforms suffer from limited elevation resolution compared to the lateral and axial resolution. We have successfully developed a dual-modal photoacoustic and ultrasound imaging to address these limitations, specifically targeting animal studies. The system can acquire whole-body images of mice in vivo and provide complementary structural and functional information of biological tissue information simultaneously. The color-coded depth information can be readily obtained in photoacoustic images using complementary information from ultrasound images. The system can be used for several biomedical applications, including drug delivery, biodistribution assessment, and agent testing. |
| first_indexed | 2024-03-09T05:20:30Z |
| format | Article |
| id | doaj.art-c346ca39d1e349e4bd7e9046f10a6710 |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-09T05:20:30Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-c346ca39d1e349e4bd7e9046f10a67102023-12-03T12:41:43ZengMDPI AGPhotonics2304-67322021-01-01811310.3390/photonics8010013Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small AnimalsEun-Yeong Park0Sinyoung Park1Haeni Lee2Munsik Kang3Chulhong Kim4Jeesu Kim5Departments of Electrical Engineering, Creative IT Engineering, Mechanical Engineering, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Gyeongbuk 37673, KoreaDepartments of Electrical Engineering, Creative IT Engineering, Mechanical Engineering, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Gyeongbuk 37673, KoreaDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, KoreaDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, KoreaDepartments of Electrical Engineering, Creative IT Engineering, Mechanical Engineering, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Gyeongbuk 37673, KoreaDepartment of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, KoreaPhotoacoustic imaging is a promising medical imaging technique that provides excellent function imaging of an underlying biological tissue or organ. However, it is limited in providing structural information compared to other imaging modalities, such as ultrasound imaging. Thus, to offer complete morphological details of biological tissues, photoacoustic imaging is typically integrated with ultrasound imaging. This dual-modal imaging technique is already implemented on commercial clinical ultrasound imaging platforms. However, commercial platforms suffer from limited elevation resolution compared to the lateral and axial resolution. We have successfully developed a dual-modal photoacoustic and ultrasound imaging to address these limitations, specifically targeting animal studies. The system can acquire whole-body images of mice in vivo and provide complementary structural and functional information of biological tissue information simultaneously. The color-coded depth information can be readily obtained in photoacoustic images using complementary information from ultrasound images. The system can be used for several biomedical applications, including drug delivery, biodistribution assessment, and agent testing.https://www.mdpi.com/2304-6732/8/1/13photoacoustic imagingultrasound imagingdual-modal imagingwhole-body imaging3D imaging |
| spellingShingle | Eun-Yeong Park Sinyoung Park Haeni Lee Munsik Kang Chulhong Kim Jeesu Kim Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small Animals Photonics photoacoustic imaging ultrasound imaging dual-modal imaging whole-body imaging 3D imaging |
| title | Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small Animals |
| title_full | Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small Animals |
| title_fullStr | Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small Animals |
| title_full_unstemmed | Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small Animals |
| title_short | Simultaneous Dual-Modal Multispectral Photoacoustic and Ultrasound Macroscopy for Three-Dimensional Whole-Body Imaging of Small Animals |
| title_sort | simultaneous dual modal multispectral photoacoustic and ultrasound macroscopy for three dimensional whole body imaging of small animals |
| topic | photoacoustic imaging ultrasound imaging dual-modal imaging whole-body imaging 3D imaging |
| url | https://www.mdpi.com/2304-6732/8/1/13 |
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