Nocardia farcinica brain abscess with torque teno virus co-infection: A case report
Background: Brain abscesses caused by Nocardia are rare and difficult to diagnose. Nocardia farcinica is among the most common species; however, the conventional diagnosis of N. farcinica infection consists of cerebrospinal fluid (CSF) and blood culture and Gram staining. These procedures prolong th...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024046632 |
| _version_ | 1827302715341930496 |
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| author | Yuting Gu Zide Wang Xiaohua Xia Guang Zhao |
| author_facet | Yuting Gu Zide Wang Xiaohua Xia Guang Zhao |
| author_sort | Yuting Gu |
| collection | DOAJ |
| description | Background: Brain abscesses caused by Nocardia are rare and difficult to diagnose. Nocardia farcinica is among the most common species; however, the conventional diagnosis of N. farcinica infection consists of cerebrospinal fluid (CSF) and blood culture and Gram staining. These procedures prolong the time to diagnosis and initiating treatment. Case presentation: A 69-year-old woman with diabetes mellitus presented with headaches and dizziness persisting for 2 weeks, which was initially diagnosed as a brain abscess. Due to the unusual presentation and rapid progression of symptoms, she underwent surgical resection of the brain abscess. No pathogens were detected in blood or CSF cultures. However, metagenomic next-generation sequencing (mNGS) identified N. farcinica and Torque teno virus in pus extracted from the abscesses. The patient received appropriate antibiotic therapy and recovered fully without any residual neurological deficits. Conclusion: mNGS useful for prompt diagnosis and selection of antibiotic therapy for brain abscesses caused by Nocardia. Surgical intervention is necessary in some cases. |
| first_indexed | 2024-04-24T16:49:55Z |
| format | Article |
| id | doaj.art-c347d8b5c47d434ab41510c9bcf1898f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T16:49:55Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c347d8b5c47d434ab41510c9bcf1898f2024-03-29T05:50:45ZengElsevierHeliyon2405-84402024-04-01107e28632Nocardia farcinica brain abscess with torque teno virus co-infection: A case reportYuting Gu0Zide Wang1Xiaohua Xia2Guang Zhao3Department of Emergency Medicine, The First People's Hospital of Kunshan, Kunshan, 215300, Jiangsu, China; The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, ChinaThe Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, ChinaDepartment of Emergency Medicine, The First People's Hospital of Kunshan, Kunshan, 215300, Jiangsu, ChinaDepartment of Emergency Medicine, The First People's Hospital of Kunshan, Kunshan, 215300, Jiangsu, China; The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China; Corresponding author. Department of Emergency Medicine, The First People's Hospital of Kunshan, Kunshan, 215300, Jiangsu, China.Background: Brain abscesses caused by Nocardia are rare and difficult to diagnose. Nocardia farcinica is among the most common species; however, the conventional diagnosis of N. farcinica infection consists of cerebrospinal fluid (CSF) and blood culture and Gram staining. These procedures prolong the time to diagnosis and initiating treatment. Case presentation: A 69-year-old woman with diabetes mellitus presented with headaches and dizziness persisting for 2 weeks, which was initially diagnosed as a brain abscess. Due to the unusual presentation and rapid progression of symptoms, she underwent surgical resection of the brain abscess. No pathogens were detected in blood or CSF cultures. However, metagenomic next-generation sequencing (mNGS) identified N. farcinica and Torque teno virus in pus extracted from the abscesses. The patient received appropriate antibiotic therapy and recovered fully without any residual neurological deficits. Conclusion: mNGS useful for prompt diagnosis and selection of antibiotic therapy for brain abscesses caused by Nocardia. Surgical intervention is necessary in some cases.http://www.sciencedirect.com/science/article/pii/S2405844024046632Nocardia farcinica infectionBrain abscessMetagenomic next-generation sequencing |
| spellingShingle | Yuting Gu Zide Wang Xiaohua Xia Guang Zhao Nocardia farcinica brain abscess with torque teno virus co-infection: A case report Heliyon Nocardia farcinica infection Brain abscess Metagenomic next-generation sequencing |
| title | Nocardia farcinica brain abscess with torque teno virus co-infection: A case report |
| title_full | Nocardia farcinica brain abscess with torque teno virus co-infection: A case report |
| title_fullStr | Nocardia farcinica brain abscess with torque teno virus co-infection: A case report |
| title_full_unstemmed | Nocardia farcinica brain abscess with torque teno virus co-infection: A case report |
| title_short | Nocardia farcinica brain abscess with torque teno virus co-infection: A case report |
| title_sort | nocardia farcinica brain abscess with torque teno virus co infection a case report |
| topic | Nocardia farcinica infection Brain abscess Metagenomic next-generation sequencing |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024046632 |
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