METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation

METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation

Dysregulated mitochondrial metabolism occurs in several pathological processes characterized by cell proliferation and migration. Nonetheless, the role of mitochondrial fission is not well appreciated in cardiac fibrosis, which is accompanied by enhanced fibroblast proliferation and migration. We in...

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Bibliographic Details
Main Authors: Bin Tu, Kai Song, Yang Zhou, He Sun, Zhi-Yan Liu, Li-Chan Lin, Ji-Fei Ding, Ji-Ming Sha, Yan Shi, Jing-Jing Yang, Rui Li, Ye Zhang, Jian-Yuan Zhao, Hui Tao
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Pharmacological Research
Subjects:
Cardiac fibroblast
YTHDF2
M6A methylation
Proliferation
Collagen
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823001962

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