Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome
BackgroundTo investigate the long-term quality of life (QoL) of children with cerebellar mutism syndrome (CMS) and explore the risk factors for a low QoL.ProcedureThis cross-sectional study investigated children who underwent posterior fossa surgery using an online Pediatric Quality of Life Inventor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1130331/full |
| _version_ | 1797895504831447040 |
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| author | Kaiyi Zhu Kaiyi Zhu Wei Yang Zesheng Ying Yingjie Cai XiaoJiao Peng Nijia Zhang Hailang Sun Yuanqi Ji Ming Ge |
| author_facet | Kaiyi Zhu Kaiyi Zhu Wei Yang Zesheng Ying Yingjie Cai XiaoJiao Peng Nijia Zhang Hailang Sun Yuanqi Ji Ming Ge |
| author_sort | Kaiyi Zhu |
| collection | DOAJ |
| description | BackgroundTo investigate the long-term quality of life (QoL) of children with cerebellar mutism syndrome (CMS) and explore the risk factors for a low QoL.ProcedureThis cross-sectional study investigated children who underwent posterior fossa surgery using an online Pediatric Quality of Life Inventory questionnaire. CMS and non-CMS patients were included to identify QoL predictors.ResultsSixty-nine patients were included (male, 62.3%), 22 of whom had CMS. The mean follow-up time was 45.2 months. Children with CMS had a significantly lower mean QoL score (65.3 vs. 83.7, p < 0.001) and subdomain mean scores (physical; 57.8 vs. 85.3, p < 0.001; social: 69.5 vs. 85.1, p = 0.001; academic: p = 0.001) than those without CMS, except for the emotional domain (78.0 vs. 83.7, p = 0.062). Multivariable analysis revealed that CMS (coefficient = −14.748.61, p = 0.043), chemotherapy (coefficient = −7.629.82, p = 0.013), ventriculoperitoneal (VP) shunt placement (coefficient = −10.14, p = 0.024), and older age at surgery (coefficient = −1.1830, p = 0.007) were independent predictors of low total QoL scores. Physical scores were independently associated with CMS (coefficient = −27.4815.31, p = 0.005), VP shunt placement (coefficient = −12.86, p = 0.025), and radiotherapy (coefficient = −13.62, p = 0.007). Emotional score was negatively associated with age at surgery (coefficient = −1.92, p = 0.0337) and chemotherapy (coefficient = −9.11, p = 0.003). Social scores were negatively associated with male sex (coefficient = −13.68, p = 0.001) and VP shunt placement (coefficient = −1.36, p = 0.005), whereas academic scores were negatively correlated with chemotherapy (coefficient = −17.45, p < 0.001) and age at surgery (coefficient = −1.92, p = 0.002). Extent of resection (coefficient = 13.16, p = 0.021) was a good predictor of higher academic scores.ConclusionCMS results in long-term neurological and neuropsychological deficits, negatively affecting QoL, and warranting early rehabilitation. |
| first_indexed | 2024-04-10T07:27:58Z |
| format | Article |
| id | doaj.art-c34bde6b18ca4ddf885dc00a885834f2 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-10T07:27:58Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychology |
| spelling | doaj.art-c34bde6b18ca4ddf885dc00a885834f22023-02-24T05:07:10ZengFrontiers Media S.A.Frontiers in Psychology1664-10782023-02-011410.3389/fpsyg.2023.11303311130331Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndromeKaiyi Zhu0Kaiyi Zhu1Wei Yang2Zesheng Ying3Yingjie Cai4XiaoJiao Peng5Nijia Zhang6Hailang Sun7Yuanqi Ji8Ming Ge9Department of Cardiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaBackgroundTo investigate the long-term quality of life (QoL) of children with cerebellar mutism syndrome (CMS) and explore the risk factors for a low QoL.ProcedureThis cross-sectional study investigated children who underwent posterior fossa surgery using an online Pediatric Quality of Life Inventory questionnaire. CMS and non-CMS patients were included to identify QoL predictors.ResultsSixty-nine patients were included (male, 62.3%), 22 of whom had CMS. The mean follow-up time was 45.2 months. Children with CMS had a significantly lower mean QoL score (65.3 vs. 83.7, p < 0.001) and subdomain mean scores (physical; 57.8 vs. 85.3, p < 0.001; social: 69.5 vs. 85.1, p = 0.001; academic: p = 0.001) than those without CMS, except for the emotional domain (78.0 vs. 83.7, p = 0.062). Multivariable analysis revealed that CMS (coefficient = −14.748.61, p = 0.043), chemotherapy (coefficient = −7.629.82, p = 0.013), ventriculoperitoneal (VP) shunt placement (coefficient = −10.14, p = 0.024), and older age at surgery (coefficient = −1.1830, p = 0.007) were independent predictors of low total QoL scores. Physical scores were independently associated with CMS (coefficient = −27.4815.31, p = 0.005), VP shunt placement (coefficient = −12.86, p = 0.025), and radiotherapy (coefficient = −13.62, p = 0.007). Emotional score was negatively associated with age at surgery (coefficient = −1.92, p = 0.0337) and chemotherapy (coefficient = −9.11, p = 0.003). Social scores were negatively associated with male sex (coefficient = −13.68, p = 0.001) and VP shunt placement (coefficient = −1.36, p = 0.005), whereas academic scores were negatively correlated with chemotherapy (coefficient = −17.45, p < 0.001) and age at surgery (coefficient = −1.92, p = 0.002). Extent of resection (coefficient = 13.16, p = 0.021) was a good predictor of higher academic scores.ConclusionCMS results in long-term neurological and neuropsychological deficits, negatively affecting QoL, and warranting early rehabilitation.https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1130331/fullcerebellar mutism syndromequality of lifePedsQLrisk factorslong-term |
| spellingShingle | Kaiyi Zhu Kaiyi Zhu Wei Yang Zesheng Ying Yingjie Cai XiaoJiao Peng Nijia Zhang Hailang Sun Yuanqi Ji Ming Ge Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome Frontiers in Psychology cerebellar mutism syndrome quality of life PedsQL risk factors long-term |
| title | Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome |
| title_full | Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome |
| title_fullStr | Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome |
| title_full_unstemmed | Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome |
| title_short | Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome |
| title_sort | long term postoperative quality of life in childhood survivors with cerebellar mutism syndrome |
| topic | cerebellar mutism syndrome quality of life PedsQL risk factors long-term |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1130331/full |
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